{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:39Z","timestamp":1788307239891,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this cohort study was to evaluate doctor\u2010diagnosed and self\u2010reported asthma in young adults after early\u2010childhood hospitalisation for wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective\u2010controlled follow\u2010up, questionnaires were sent to 95\u00a0subjects aged 24\u201328\u00a0years, who had been hospitalised for their first episodes of wheezing under 24\u00a0months of age. Fifty\u2010eight cases and 100 controls returned the questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of doctor\u2010diagnosed asthma was 2.14\u2010fold (95% confidence interval 0.61\u20137.41), and the risk of self\u2010reported asthma 2.39\u2010fold (1.14\u20134.99) in cases compared to controls. The increased risk of self\u2010reported asthma remained as statistically significant in analyses adjusted for current smoking, overweight and allergic rhinitis. Study subjects presented with wheezing symptoms, use of bronchodilators and inhaled corticosteroids, and with seasonal symptoms presumptive for allergic rhinitis during the last 12\u00a0months, more often than controls. The identification of a respiratory syncytial virus or rhinovirus during hospitalisation in early childhood was not anymore associated with asthma risk in adulthood. As expected, previous asthma during early childhood was a strong risk factor for asthma in young adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this controlled questionnaire study, early\u2010childhood hospitalisation for lower respiratory infection with wheezing was an independently significant risk factor of asthma in young adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16099","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T20:05:11Z","timestamp":1631131511000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An increased asthma risk continued until young adulthood after early\u2010childhood hospitalisation for wheezing"],"prefix":"10.1111","volume":"111","author":[{"given":"Marja","family":"Ruotsalainen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital and University 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