{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:54:57Z","timestamp":1775159697053,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It can be challenging to distinguish COVID\u201019 in children from other common infections. We set out to determine the rate at which children consulting a primary care paediatrician with an acute infection are infected with SARS\u2010CoV\u20102 and to compare distinct findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In seven out\u2010patient clinics, children aged 0\u201313\u00a0years with any new respiratory or gastrointestinal symptoms and presumed infection were invited to be tested for SARS\u2010CoV\u20102. Factors that were correlated with testing positive were determined. Samples were collected from 25 January 2021 to 01 April 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred and eighty\u2010three children participated in the study (median age 3\u00a0years and 0\u00a0months, range 1\u00a0month to 12\u00a0years and 11\u00a0months). Three hundred and fifty\u2010eight were female (45.7%). SARS\u2010CoV\u20102 RNA was detected in 19 (2.4%). The most common symptoms in children with as well as without detectable SARS\u2010CoV\u20102 RNA were rhinitis, fever and cough. Known recent exposure to a case of COVID\u201019 was significantly correlated with testing positive, but symptoms or clinical findings were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 among the children with symptoms of an acute infection was uncommon, and the clinical presentation did not differ significantly between children with and without evidence of an infection with SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16101","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T18:23:17Z","timestamp":1631730197000},"page":"3315-3321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["COVID\u201019 among children seeking primary paediatric care with signs of an acute infection"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-9385","authenticated-orcid":false,"given":"Sebastian","family":"Hoehl","sequence":"first","affiliation":[{"name":"Institute of Medical Virology Goethe University Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology Goethe University Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Eckrich","sequence":"additional","affiliation":[{"name":"Praxisgemeinschaft f\u00fcr Kinder\u2010 und Jugendmedizin Dres, Martin Eckrich &amp; Tim Gr\u00fcndler Offenbach\u2010Rumpenheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim Ole","family":"Gr\u00fcndler","sequence":"additional","affiliation":[{"name":"Praxisgemeinschaft f\u00fcr Kinder\u2010 und Jugendmedizin Dres, Martin Eckrich &amp; Tim Gr\u00fcndler Offenbach\u2010Rumpenheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pera Silvija","family":"Jerkic","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter Allergologie, P\u00e4diatrische Pneumologie, Kinderheilkunde und Jugendmedizin Bad Homburg v.d.H Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geri","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Kinder &amp; Jugendarzt Dr. med. Geri Lichtenstein Eschborn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Melcher","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Kinder\u2010 und Jugendmedizin Dres. Birgit und Hansj\u00f6rg Melcher Bad Soden am Taunus Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansj\u00f6rg","family":"Melcher","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Kinder\u2010 und Jugendmedizin Dres. Birgit und Hansj\u00f6rg Melcher Bad Soden am Taunus Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Moebus","sequence":"additional","affiliation":[{"name":"Kinder\u2010 und Jugendarzt Dr. Ralf Moebus Bad Homburg v.d.H Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"M\u00fchlfeld","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter Allergologie, P\u00e4diatrische Pneumologie, Kinderheilkunde und Jugendmedizin Bad Homburg v.d.H Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilonka","family":"Rieger","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter Allergologie, P\u00e4diatrische Pneumologie, Kinderheilkunde und Jugendmedizin Bad Homburg v.d.H Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Seger\u2010Fritz","sequence":"additional","affiliation":[{"name":"Kinderarztpraxis Seger\u2010Fritz Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Sgoll","sequence":"additional","affiliation":[{"name":"Kinderarztpraxis Dr. Sgoll Gr\u00fcndau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Walter","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter Allergologie, P\u00e4diatrische Pneumologie, Kinderheilkunde und Jugendmedizin Bad Homburg v.d.H Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Werner","sequence":"additional","affiliation":[{"name":"Kinderarztpraxis Dr. Sgoll Gr\u00fcndau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Mathematical Modeling Goethe University Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie","family":"Berger","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology Goethe University Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-7565","authenticated-orcid":false,"given":"Sandra","family":"Ciesek","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology Goethe University Frankfurt Frankfurt am Main Germany"},{"name":"Branch Translational Medicine and Pharmacology Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Frankfurt am Main Germany"},{"name":"German Center for Infection Research, DZIF Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1467"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24885"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00066-3"},{"key":"e_1_2_9_6_1","first-page":"cmaj.202065","article-title":"Symptoms associated with a positive result for a swab for SARS\u2010CoV\u20102 infection among children in Alberta","volume":"193","author":"King JA","year":"2020","journal-title":"CMAJ"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15270"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6950e3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.003"},{"key":"e_1_2_9_10_1","unstructured":"Robert Koch Institute.Coronavirus Disease 2019 (COVID\u201019) Weekly Situation Report of the Robert Koch Institute Calendar Week 11\/2021 \u2010 Update Status for Germany(n.d.).https:\/\/www.rki.de\/DE\/Content\/InfAZ\/N\/Neuartiges_Coronavirus\/Situationsberichte\/Maerz_2021\/2021\u201003\u201018\u2010en.pdf?__blob=publicationFile"},{"key":"e_1_2_9_11_1","unstructured":"Robert Koch Institut.Influenza\u2010Wochenbericht der Arbeitsgemeinschaft Influenza \u2010 Kalenderwoche 13.https:\/\/influenza.rki.de\/Wochenberichte\/2020_2021\/2021\u201013.pdf. 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