{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:37:43Z","timestamp":1785015463487,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal encephalopathy (NE) is associated with an increased risk of multi\u2010organ injury. The lack of standardised definitions for multi\u2010organ dysfunction in NE hinders accurate quantification of these complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A simple multi\u2010organ dysfunction in neonatal encephalopathy scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems with a maximum score of 15. The MODE score was then compared with the grade of NE, Bayley Scales of Infant Development (Bayley\u2010III) at 2\u00a0years of age and mortality. The Bayley score was used as it gave an objective score making it easier to compare the MODE score. Bayley score of &lt;90 and\/or abnormal MRI as an adverse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants with perinatal asphyxia (PA:<jats:italic>n<\/jats:italic>\u00a0=\u00a085) were prospectively enrolled (PA only <jats:italic>n<\/jats:italic>\u00a0=\u00a09; NE I\u00a0=\u00a023; NE II\u00a0=\u00a042; NE III\u00a0=\u00a011). Infants with higher MODE scores were significantly more likely to have moderate\/severe NE (NE II\/III: median scores (IQR) 7(5\u201310) versus mild NE 2 (1\u20133); <jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a00.001) The MODE score was highly predictive of mortality (AUC 0.96, <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.002). Infants who had an abnormal neurological examination at discharge or abnormal Bayley\u2010III scores had significantly higher MODE scores (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantifying multi\u2010organ injury is important to plan optimal early management and long\u2010term follow\u2010up. Additional use of clinical biomarkers may be useful as surrogate endpoints in future clinical trials and link to multi\u2010organ longer\u2010term developmental follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16111","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T07:40:41Z","timestamp":1631778041000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multi\u2010organ dysfunction scoring in neonatal encephalopathy (MODE Score) and neurodevelopmental outcomes"],"prefix":"10.1111","volume":"111","author":[{"given":"Deirdre Una","family":"Sweetman","sequence":"first","affiliation":[{"name":"Neonatology National Maternity Hospital Dublin Ireland"},{"name":"National Children\u2019s Research Centre Dublin 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