{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:29Z","timestamp":1747183289384,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The potential for immunotherapy to prevent asthma development has become a hot topic. This prompted us to revisit data from an early study that examined allergic sensitisation on bronchial hyperresponsiveness (BHR) in children with and without respiratory symptoms. Unlike previous studies, it used both indirect and direct test methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted in Kuopio, Finland, in 1994 and 247 children (55.1% boys) with a mean age 10.5\u00a0\u00b1\u00a01.7\u00a0years were recruited using a school survey: 165 with lower respiratory symptoms and 82 healthy controls. Each child underwent a 6\u2010min free\u2010running test and a methacholine test with a cumulative dose of 4900\u00a0\u00b5g. All participants underwent skin\u2010prick tests: 127were sensitised and 120 were non\u2010sensitised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in lung function between the sensitised and non\u2010sensitised children. However, sensitisation was associated with BHR which was measured by both the methacholine test (2400\u00a0\u00b5g versus &gt;4900\u00a0\u00b5g, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and the free\u2010running test (\u22123.5% versus \u22122.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.042). No such differences were observed among the healthy controls. Sensitisation was a predictor of allergic diseases, and only multisensitisation to a minimum of four allergens increased the incidence of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allergic sensitisation did not affect BHR in children without respiratory symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16129","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T17:44:07Z","timestamp":1632937447000},"page":"424-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allergic sensitisation did not affect bronchial hyper\u2010responsiveness in children without respiratory tract symptoms"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-455X","authenticated-orcid":false,"given":"Janne I.","family":"Burman","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-5639","authenticated-orcid":false,"given":"Sami T.","family":"Remes","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-3111","authenticated-orcid":false,"given":"Mika J.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1071"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12895"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.06.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.4.181"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70114-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.05.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13516"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.046"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12557"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2015.7.4.339"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13755"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2012.10.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.04.028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13072"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12994"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.11.030"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.10.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.2.120"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13891.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14195.x"},{"key":"e_1_2_9_22_1","first-page":"395","article-title":"Terveiden suomalaislasten spirometrian ja uloshengityksen huippuvirtauksen viitearvot","volume":"5","author":"Koillinen H","year":"1998","journal-title":"Suom L\u00e4\u00e4k\u00e4rilehti"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01526\u20102016"},{"key":"e_1_2_9_24_1","unstructured":"HalkenS Larenas\u2010LinnemannD RobertsG et al.EAACI allergen immunotherapy 365 guideline part 2: chapter 1: prevention of allergy p 4\u201018. 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