{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:46:13Z","timestamp":1768805173771,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Several countries, such as Norway and Sweden, have not implemented universal varicella vaccination. We present data for Norway and Sweden that were generated by a paediatric multi\u2010country Phase III study over a 10\u2010year period. This assessed the efficacy, antibody persistence and safety of two varicella vaccines containing the same Oka strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observer\u2010blind, controlled trial conducted in 10 European countries. Children aged 12\u201322\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a05803) were randomised 3:3:1 and vaccinated between 1 September 2005 and 10\u00a0May 2006. The two\u2010dose group received two tetravalent measles\u2010mumps\u2010rubella\u2010varicella vaccine doses. The one\u2010dose group received one monovalent varicella vaccine dose after a measles\u2010mumps\u2010rubella vaccine dose. Control group participants received two measles\u2010mumps\u2010rubella vaccine doses. Main study outcomes were vaccine efficacy against confirmed varicella cases and incidence of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vaccine efficacy in the two\u2010dose group was \u226592.1% in both Norwegian and Swedish children compared to 72.3% in Norway and 58.0% in Sweden in the one\u2010dose group. Incidences of adverse events and serious adverse events were similar in the Norwegian and Swedish study populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consistent with overall study results, high efficacy against varicella and acceptable safety profiles of the two varicella vaccines were observed in Norwegian and Swedish populations. These findings highlight the benefits of varicella vaccines, particularly when administered as a two\u2010dose schedule.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16136","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T19:41:14Z","timestamp":1633462874000},"page":"391-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Randomised controlled trial showed long\u2010term efficacy, immunogenicity and safety of varicella vaccines in Norwegian and Swedish children"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-8969","authenticated-orcid":false,"given":"Giacomo","family":"Casabona","sequence":"first","affiliation":[{"name":"GSK Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Ahsan","family":"Habib","sequence":"additional","affiliation":[{"name":"GSK Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Povey","sequence":"additional","affiliation":[{"name":"GSK Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne A.","family":"Riise Bergsaker","sequence":"additional","affiliation":[{"name":"The Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-4766","authenticated-orcid":false,"given":"Carl\u2010Erik","family":"Flodmark","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketil Arne","family":"Espnes","sequence":"additional","affiliation":[{"name":"Risvollan Legesenter Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"T\u00f8ndel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-3797","authenticated-orcid":false,"given":"Sven\u2010Arne","family":"Silfverdal","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Paediatrics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2019-000433"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-31"},{"key":"e_1_2_12_4_1","first-page":"265","article-title":"Varicella and herpes zoster vaccines: WHO position paper, June 2014","volume":"89","author":"World Health Organization","year":"2014","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.041"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1394843"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2445-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1581-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1957-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001656"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.07.012"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002233"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2019.1573145"},{"key":"e_1_2_12_14_1","unstructured":"Finnish Institute for Health and Welfare.Infectious diseases and vaccinations: Varicella vaccine. 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