{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:53:14Z","timestamp":1790934794253,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C), a rare severe complication of SARS\u2010CoV\u20102 infection, has been recently reported to mimic acute abdomen and lead to surgical interventions, posing challenges for clinicians. In this systematic review, we evaluated the rate of acute abdomen and abdominal surgical emergencies in children with MIS\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review of all MIS\u2010C cases presented with acute abdomen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 385 patients with MIS\u2010C, from 38 studies, were included. Gastrointestinal manifestations were prominent in 233\/385 (60.5%) children. Acute abdomen was noted in 72\/385 (18.7%) of MIS\u2010C cases and in 72\/233 (30.9%) of MIS\u2010C cases with gastrointestinal symptoms. Final diagnoses were mostly non\u2010surgical (55\/72, 76.4%), such as mesenteric lymphadenitis (23\/72, 31.9%), terminal ileitis\/ileocolitis (19\/72, 26.4%), free abdominal fluid\/ascites (8\/72, 11.1%) and paralytic ileus (3\/72, 4.2%). Laparotomy was performed in 35\/72 (48.6%) of children with MIS\u2010C, and acute abdomen and was proven unnecessary in 18\/35 (51.4%) cases. True abdominal surgical emergencies, such as appendicitis and obstructive ileus, were confirmed in 17\/72 (23.6%) cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MIS\u2010C often presents with acute abdomen, mostly due to non\u2010surgical intestinal inflammatory pathology. However, surgical complications occur in patients with MIS\u2010C; therefore, a high index of suspicion should remain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16178","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T16:34:21Z","timestamp":1636475661000},"page":"467-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Acute abdomen in multisystem inflammatory syndrome in children: A systematic review"],"prefix":"10.1111","volume":"111","author":[{"given":"Glykeria","family":"Rouva","sequence":"first","affiliation":[{"name":"Department of Paediatrics University General Hospital of Heraklion Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-0328","authenticated-orcid":false,"given":"Eleni","family":"Vergadi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University General Hospital of 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