{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:12:09Z","timestamp":1783440729935,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N\u2010acetylcysteine treatment in young children suspected of paracetamol poisoning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of children aged 0\u20136\u00a0years suspected of paracetamol poisoning with a related plasma\u2010paracetamol measurement in the Capital Region of Denmark in the period 2010\u20132017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 297 children included, suspected single paracetamol overdoses were present in 281 (95%). Sixty\u2010nine per cent were treated with N\u2010acetylcysteine, and the mean treatment period was 20.3\u00a0h (SD 20.8). A maximum of 6 (2%) of the children suspected of single overdose had plasma\u2010paracetamol concentrations that exceeded the recommended treatment thresholds. No cases of severe hepatotoxicity were registered. Adverse events to N\u2010acetylcysteine\u2010treatment were registered in 3 (2%) children including one anaphylactoid reaction (0.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that initiating N\u2010acetylcysteine as a \u2018one size fit all\u2019 treatment regimen in all children aged 0\u20136\u00a0years with a suspected single paracetamol overdose leads to substantial overtreatment. The data support that it is feasible to initiate N\u2010acetylcysteine within 10\u00a0h based on an early plasma\u2010paracetamol test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16185","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T08:35:24Z","timestamp":1636792524000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Has the time come to stop routine N\u2010acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0\u20136 years"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-6158","authenticated-orcid":false,"given":"Christina","family":"Gade","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"B\u00f8gevig","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-4028","authenticated-orcid":false,"given":"Alaa","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille R.","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital, Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Copenhagen Center for Translational Research Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim P.","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonny S.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-015-0049-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2018.1533727"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3551"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.4.346"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70479-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13028"},{"key":"e_1_2_9_8_1","first-page":"131","article-title":"Acetaminophen\u2010induced hepatotoxicity: a comprehensive update","volume":"4","author":"Yoon E","year":"2016","journal-title":"J Clin Transl Hepatol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01625.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003328.pub3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90612-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6198.1097"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2218"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.659252"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1984.02140430006003"},{"key":"e_1_2_9_16_1","first-page":"6892","article-title":"Recommendations for treatment of paracetamol poisoning. 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