{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:44Z","timestamp":1761986564058,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The main objective of this study was to see how many of the children, with a suspected antibiotic allergy, developed an allergic or adverse reaction to a drug provocation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on children that had undergone a drug provocation test for a suspected antibiotic allergy were compiled retrospectively for the period from 2007\u20132018. The median age at the first provocation was 2.25\u00a0years (1.5\u20135.7). Standardised questionnaires, the children's parents had answered before the provocation, were used to evaluate the originally suspected allergic reaction, previous health, atopic diseases and family history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two (6.4%) of the 1440 children showed a possible mild allergic reaction. Sixty\u2010four of the 92 children underwent a second drug provocation test 1\u20132\u00a0years later. At that time, only eleven developed a positive\u2010 or a possible\u2010delayed reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An immediate moderate or severe allergic reaction was excluded in all cases of suspected antibiotic allergy in this study. Our study indicates that an oral drug provocation test is safe. It may be appropriate to wait for 6\u00a0months or more after the initial\u00a0event of ADR\u00a0before these tests are performed.\u00a0A second oral provocation 1\u20132\u00a0years after the first one\u00a0shows\u00a0that\u00a0ADRs\u00a0are outgrown in\u00a0most\u00a0children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16211","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:29:25Z","timestamp":1638970165000},"page":"1056-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antibiotic oral provocation challenge in children"],"prefix":"10.1111","volume":"111","author":[{"given":"Gy\u00f0a Katr\u00edn","family":"Gu\u00f0nad\u00f3ttir","sequence":"first","affiliation":[{"name":"University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"J\u00f3nasson","sequence":"additional","affiliation":[{"name":"University of Iceland  Reykjavik Iceland"},{"name":"Children\u2019s Hospital Iceland Landsp\u00edtalinn University Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Clausen","sequence":"additional","affiliation":[{"name":"University of Iceland  Reykjavik Iceland"},{"name":"Children\u2019s Hospital Iceland Landsp\u00edtalinn University Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonie Gertin","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Iceland Landsp\u00edtalinn University Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-6303","authenticated-orcid":false,"given":"Sigur\u00f0ur","family":"Kristj\u00e1nsson","sequence":"additional","affiliation":[{"name":"University of Iceland  Reykjavik Iceland"},{"name":"Children\u2019s Hospital Iceland Landsp\u00edtalinn 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