{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:04:41Z","timestamp":1760385881630,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to retrospectively compare how many cases of early\u2010onset sepsis (EOS) would have been predicted by the the Kaiser\u2010Permanente (KP) calculator and the United States Centers for Disease Control and Prevention (CDC) guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational retrospective cohort study comprised 50 newborn infants with documented EOS who were born at the Kaplan Medical Centre, Israel, between 2001 and 2018. We retrospectively evaluated whether the KP calculator and the CDC recommendations would have recommended antibiotic treatment if they had been implemented within four hours of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EOS was diagnosed in 50 of the 109\u00a0877 infants born from 34\u00a0weeks of gestation. By four hours of birth, 18 were symptomatic, five had an equivocal clinical status, and 27 were asymptomatic. The KP calculator would have recommended antibiotic treatment for 19 (38%) neonates: 18 who were symptomatic and one who was initially asymptomatic. The CDC guidelines would have recommended antibiotic treatment for 27 (54%) nenonates: those 19 plus all 5 with equivocal status and other 3 who were asymptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using the CDC guidelines would have identified more equivocal and asymptomatic EOS cases within four hours of birth than the KP calculator. Enhanced observation is recommended when using the KP calculator.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16232","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T18:13:43Z","timestamp":1640110423000},"page":"767-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Centers for disease control and prevention guidelines identified more neonates at risk of early\u2010onset sepsis than the Kaiser\u2010Permanente calculator"],"prefix":"10.1111","volume":"111","author":[{"given":"Calanit","family":"Hershkovich\u2013Shporen","sequence":"first","affiliation":[{"name":"Department of Neonatology Kaplan Medical Centre  Rehovot Israel"},{"name":"The Hebrew University School of Medicine Hebrew University and Hadassah Medical Centre  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-4554","authenticated-orcid":false,"given":"Alex","family":"Guri","sequence":"additional","affiliation":[{"name":"The Hebrew University School of Medicine Hebrew University and Hadassah Medical Centre  Jerusalem Israel"},{"name":"Department of Paediatrics Kaplan Medical Centre  Rehovot Israel"},{"name":"Infectious Diseases Unit Kaplan Medical Centre  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Gluskina","sequence":"additional","affiliation":[{"name":"The Hebrew University School of Medicine Hebrew University and Hadassah Medical Centre  Jerusalem Israel"},{"name":"Department of Paediatrics Kaplan Medical Centre  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2790-9727","authenticated-orcid":false,"given":"Orna","family":"Flidel\u2010Rimon","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kaplan Medical Centre  Rehovot Israel"},{"name":"The Hebrew University School of Medicine Hebrew University and Hadassah Medical Centre  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318223bad2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.96"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(16)42030-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1866"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2217"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00043-09"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000068206.11303.dd"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3423"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.06.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_1_17"},{"issue":"10","key":"e_1_2_9_14_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease\u2010\u2010revised guidelines from CDC, 2010","volume":"59","author":"Verani JR","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1649650"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002236"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304629"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317165"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.11.045"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1651281"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.137"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002590"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2018-0201"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i4.358"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.16232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T23:04:45Z","timestamp":1692572685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/apa.16232"],"URL":"https:\/\/doi.org\/10.1111\/apa.16232","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2021,12,31]]},"assertion":[{"value":"2021-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}