{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T17:25:11Z","timestamp":1776619511575,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["180021"],"award-info":[{"award-number":["180021"]}],"id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["200137"],"award-info":[{"award-number":["200137"]}],"id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed psychosocial burdens in children who developed narcolepsy after receiving the Pandemrix H1N1 vaccine during the 2009\u20132010 pandemic. Parental quality of life was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre study covered four of the five Finnish University Hospital Districts, which dealt with about 90% of the paediatric narcolepsy cases after the Pandemrix vaccination. The medical records of children diagnosed from 2010 to 2014 were reviewed. The questionnaires included the Youth Self\u2010Report (YSR), Children's Depression Inventory (CDI), the Child Behaviour Checklist (CBCL) and questions on parental resources, stress and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We obtained the medical records of 94 children who were aged 5\u201317\u00a0years at the time of their narcolepsy diagnosis and questionnaire data for 73 of those children. Most children had strong narcolepsy symptoms, and 25% had CDI scores that suggested depression. In addition, 41% had total CBCL problem scores above the clinically significant limit and 48% were anxious, withdrawn and had somatic complaints. Sleep latency was weakly associated with the CBCL total problem score. Half of the children needed psychiatric interventions and parental stress was common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression and behavioural problems were common in children with narcolepsy after the Pandemrix vaccination and their parents frequently reported feeling stressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16233","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T18:15:17Z","timestamp":1640110517000},"page":"850-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Finnish children who experienced narcolepsy after receiving the Pandemrix vaccine during the 2009\u20132010 H1N1 pandemic demonstrated high level of psychosocial problems"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-7970","authenticated-orcid":false,"given":"Marita","family":"Hovi","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology New Children's Hospital and Paediatric Research Centre University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Heiskala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology New Children's Hospital and Paediatric Research Centre University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva T.","family":"Aronen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Psychiatry New Children's Hospital and Paediatric Research Centre University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"Saarenp\u00e4\u00e4\u2010Heikkil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University of Tampere  Tampere Finland"},{"name":"Department of Paediatrics Tampere University Hospital  Tampere Finland"},{"name":"Faculty of Medicine and Life Sciences Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University of Oulu and Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Nokelainen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University of Kuopio and Kuopio University Hospital  Kuopio 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