{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:53Z","timestamp":1747183313255,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the prevalence of discomfort in infants with severe bronchiolitis supported by noninvasive ventilation and to identify its potential risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre retrospective observational study. Discomfort was assessed using the EDIN (Echelle de Douleur et d'Inconfort du Nouveau\u2010n\u00e9) scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one infants (median age 34\u00a0days [Interquartile IQR 19\u201355], 52 (57%) boys) were included in our study. Overall, no patient had a mean EDIN score higher than 8 on Days 1, 2 and 3. On Days 1 and 2, patients supported by bilevel positive airway pressure (BiPAP) had a higher EDIN score compared with other patients (3.3 [SD 2.5] versus 2.6 [SD 2.2] on Day 1 and 2.9 (SD 2.1) versus 2.3 (SD 2.2) on Day 2, both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with severe bronchiolitis and supported by any type of noninvasive ventilation had a low degree of discomfort during the first 3\u00a0days of ICU stay. Patients requiring bilevel noninvasive ventilation appeared to have a higher degree of discomfort, while we found no correlation between the level of discomfort and the degree of respiratory distress.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16305","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T06:33:01Z","timestamp":1645252381000},"page":"1238-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and risk factors of discomfort in infants with severe bronchiolitis"],"prefix":"10.1111","volume":"111","author":[{"given":"Justine","family":"Leboucher","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Mil\u00e9si","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Debillon","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-5330","authenticated-orcid":false,"given":"Guillaume","family":"Mortamet","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Grenoble\u2010Alpes University Hospital  Grenoble France"},{"name":"Univ. 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