{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T13:12:38Z","timestamp":1737292358602,"version":"3.33.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A lack of stored iron, indicated by low serum ferritin, has been associated with various clinical symptoms. There are no longitudinal data on the frequency of ferritin measurements in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2834 children aged &lt;18\u2009years with serum ferritin and other anaemia\u2010related blood parameters taken during an outpatient visit between 2012 and 2019 were investigated. Patients with acute infections were excluded. Nationwide temporal and regional variations and correlations with public information searches through Google were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increase in the frequency of ferritin measurements was seen starting in 2018, with a 47\u2010fold rise in 2019 compared to 2012. A simultaneous escalation in Google Search activity was seen. Deficiency of stored iron was relatively common: 21.6% of children with normal haemoglobin and 14.9% of non\u2010anaemic children with normal red cell indices exhibited ferritin levels below 15\u2009\u03bcg\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ferritin measurement has increased greatly among children and adolescents. Our results suggest that public interest and popular trends can significantly influence health care practices. This calls for further investigation into the causes and consequences of such a phenomenon. Prospective randomised intervention studies are needed to evaluate the utility of iron supplementation in patients with low iron storage levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16454","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T09:34:50Z","timestamp":1655372090000},"page":"1933-1940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in ferritin measurements in children and adolescents: A\u00a0Finnish 9\u2010year observational study"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-2386","authenticated-orcid":false,"given":"Atte","family":"Nikkil\u00e4","sequence":"first","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-0797","authenticated-orcid":false,"given":"Olli","family":"Lohi","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niina","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Terveystalo Healthcare  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0819-7875","authenticated-orcid":false,"given":"P\u00e9ter","family":"Csonka","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"},{"name":"Terveystalo Healthcare  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1182\/blood.V99.10.3505"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/j.blre.2008.08.001"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1146\/annurev.nutr.28.061807.155521"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1182\/blood-2009-11-253815"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1002\/14651858.CD011817.pub2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1111\/joim.13004"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1182\/blood.V49.1.147.147"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1136\/bmjopen-2017-019240"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1111\/apa.12173"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1503\/cmaj.110950"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1016\/j.sleep.2013.06.006"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/j.earlhumdev.2007.12.009"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1093\/pch\/17.4.193"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1007\/s12031-019-01276-1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1016\/j.jpeds.2013.05.015"},{"unstructured":"Centers for Disease Control and Prevention (CDC).Recommendations to prevent and control iron deficiency in the United States.1998.https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/00051880.htm. 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