{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:03:40Z","timestamp":1759147420768,"version":"3.33.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Adherence to croup management recommendations has been poorly investigated. This study aimed to describe the treatment patterns in two paediatric emergency departments and analyse the adherence to recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective chart review of children diagnosed with croup in two Italian paediatric emergency departments in 2017. Data on clinical presentation, corticosteroid administration and home therapy were collected. Length of stay, hospitalisation and re\u2010access rates were compared among different corticosteroid treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 632 patients (61.1% males) with a mean age of 42.8\u00a0\u00b1\u200955.1\u2009months. Corticosteroids were administered to 403 (63.8%) children in the emergency departments. Dexamethasone was administered to 1 (0.4%) patient. Inhaled and oral corticosteroids were given to 342 (54.1%) and 226 (35.8%) patients, respectively. Home therapy was prescribed for 603 (95.4%) patients, either with inhaled (86.2%) and\/or oral (43.8%) corticosteroids. The re\u2010access rate was 2.8%. The actual pharmaceutical costs were an estimated 10 times higher than they would have been if the recommendations had been followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant gap between the evidence and clinical practice for croup treatment was observed. Improving adherence to the recommendations could lead to clinical and economic benefits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16468","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T08:39:43Z","timestamp":1656146383000},"page":"2010-2016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multicentre study revealed significant gaps between evidence\u2010based recommendations for using corticosteroids for croup and clinical practice"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-5488","authenticated-orcid":false,"given":"Luca","family":"Pierantoni","sequence":"first","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Stera","sequence":"additional","affiliation":[{"name":"Specialty School of Paediatrics, Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-9652","authenticated-orcid":false,"given":"Laura","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Dondi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Fabi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Corsini","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Ghizzi","sequence":"additional","affiliation":[{"name":"Pediatric Unit Ospedale Maggiore  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Lanari","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1056\/NEJMcp072022"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1016\/S0140-6736(08)60170-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1016\/j.jpeds.2007.10.043"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1542\/peds.83.5.683"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1042\/cs0940557"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1001\/jamapediatrics.2019.0834"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1002\/14651858.CD001955.pub4"},{"unstructured":"simri.it.Il CROUP o Laringite ipoglottica. (The CROUP or Hypoglottic Laryngitis Italian Society for Childhood Respiratory Diseases) [online];2012.https:\/\/simri.it\/simri\/idPage\/159\/idNews\/10\/Il\u2010CROUP\u2010o\u2010Laringite\u2010ipoglottica.html[Accessed 4 March 2022].","key":"e_1_2_10_9_1"},{"unstructured":"Sipps.it.L'uso dei corticosteroidi inalatori in et\u00e0 evolutiva. (The use of inhaled corticosteroids in children and adolescents.) [Online];2019.https:\/\/www.sipps.it\/pdf\/editoriale\/SIP40_BASSA_guidaCORTICOSTEROIDI_210917.pdf[Accessed 5 April 2022].","key":"e_1_2_10_10_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1093\/intqhc\/mzz088"},{"issue":"5","key":"e_1_2_10_12_1","first-page":"269","article-title":"Croup","volume":"39","author":"Charles J","year":"2010","journal-title":"Aust Fam Physician"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1186\/s13052-017-0348-x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1080\/00220973.1995.9943797"},{"unstructured":"BMJ Best Practice.Croup [online];2019.https:\/\/bestpractice.bmj.com\/topics\/en\u2010us\/681[Accessed 16 April 2022].","key":"e_1_2_10_15_1"},{"unstructured":"Sahealth.sa.gov.au.South Australian Paediatric clinical practice guidelines. 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