{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:37:02Z","timestamp":1783121822722,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate associations between iron status and gross motor scores in infants aged 3\u20137\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study, 252 infants aged 3\u20137\u2009months were examined using the age\u2010standardised Alberta Infant Motor Scale (AIMS) prior to analysing iron status in 250 infants. Combined AIMS and ferritin results were assessed in 226 infants, whereas AIMS and reticulocyte haemoglobin (ret\u2010Hb) results were obtained for 61 infants. We used logistic regressions and receiver operator characteristics to analyse our data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With AIMS <jats:italic>z<\/jats:italic>\u2010score &lt;10th percentile as outcome measure, optimal cut\u2010off value for ferritin was 51\u2009\u03bcg\/L (sensitivity 86%, specificity 81%) and 28\u2009pg for ret\u2010Hb (sensitivity 86%, specificity 85%). The area under the curve for ferritin and ret\u2010Hb was 0.886 and 0.896, respectively (<jats:italic>n<\/jats:italic>\u00a0=\u200961). Ferritin &lt;51\u2009\u03bcg\/L predicted an AIMS <jats:italic>z<\/jats:italic>\u2010score &lt;10th percentile in a logistic regression (OR 3.3, 95% CI 1.4\u20137.5, <jats:italic>p<\/jats:italic>\u00a0=\u20090.006, <jats:italic>n<\/jats:italic>\u00a0=\u2009226). Six of 14 (43%) infants with ret\u2010Hb &lt;28\u2009pg scored &lt;10th percentile on AIMS compared to 1\/47 (2.1%) infants with ret\u2010Hb \u226528\u2009\u03bcg\/L (Exact, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reticulocyte haemoglobin of &lt;28\u2009pg and ferritin &lt;51\u2009\u03bcg\/L were associated with suboptimal gross motor scores in infants 3\u20137\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16469","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T09:25:52Z","timestamp":1656494752000},"page":"1941-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lower iron stores were associated with suboptimal gross motor scores in infants at 3\u20137 months"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-9952","authenticated-orcid":false,"given":"Ulf Wike","family":"Ljungblad","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Paediatrics Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Tangeraas","sequence":"additional","affiliation":[{"name":"Norwegian National Unit for Newborn Screening, Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPED.2018.08.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3547"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(94)70003-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00301-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.8.1974"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1681028"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCA.2020.01.032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.4.1489"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000749"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU13113737"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2021.10.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.01.032"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.03.003"},{"key":"e_1_2_9_16_1","volume-title":"Alberta Infant Motor Scale (AIMS): Motor Assessment of the Developing Infant","author":"Piper MC","year":"1994"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb15399.x"},{"key":"e_1_2_9_18_1","volume-title":"Pediatric Reference Intervals","author":"Soldin SJ","year":"2011"},{"key":"e_1_2_9_19_1","volume-title":"Tietz Clinical Guide to Laboratory Tests Fourth Edition","author":"Wu A","year":"2006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2013.769625"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02641.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.242"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-321672"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/PR.2012.162"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1818216"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.8.924"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.12.3680"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.05.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/JOIM.13011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001454"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15127"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000206"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1651-2227.2004.TB02983.X"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.16469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:10:13Z","timestamp":1737173413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/apa.16469"],"URL":"https:\/\/doi.org\/10.1111\/apa.16469","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"assertion":[{"value":"2022-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}