{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:43:19Z","timestamp":1792723399170,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is weak evidence that proton pump inhibitors (PPIs) alleviate non\u2010specific complaints often attributed to gastroesophageal reflux in infancy and international guidelines do not recommend their use. We studied PPIs dispensed for infants in three Nordic countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an observational population\u2010based study of infants living in Norway, Sweden and Denmark in 2007\u20132020. We used nationwide pharmaceutical registers to study dispensed PPIs. The data provided a total of 3.3 million observed years on about 240\u2009000 annual births.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall use of PPIs in infancy showed a marked increase in all three countries from 2007 to 2020. In 2020, PPI dispensing was 46.4, 23.4 and 18.9 per 1000 per year in infants aged 0\u201311\u00a0months in Denmark, Norway and Sweden. These were increases of 357%, 585% and 556% respectively. Although the rate was highest in Denmark, it had decreased by 42% in the last 3\u2009years of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite international recommendations against routine PPI prescribing in infancy, dispensed PPIs increased more than fourfold on average in three Nordic countries from 2007 to 2020. The reason for this notable increase could not be established from the data, but the large variations over time, and between the countries, probably indicated unwarranted use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.16491","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T03:44:20Z","timestamp":1658375060000},"page":"2222-2228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Proton pump inhibitors for infants in three Scandinavian countries increased from 2007 to 2020 despite international recommendations"],"prefix":"10.1111","volume":"111","author":[{"given":"Miriam","family":"Lyamouri","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"M\u00e5rild","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sahlgrenska Academy Gothenburg University  Gothenburg Sweden"},{"name":"Department of Pediatric Gastroenterology Queen Silvia Children's Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus Gaardsk\u00e6r","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-8646","authenticated-orcid":false,"given":"Ketil","family":"St\u00f8rdal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research University of Oslo  Oslo Norway"},{"name":"Division of Pediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181c2bf41"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001889"},{"key":"e_1_2_10_4_1","article-title":"Pharmacological treatment of children with gastro\u2010oesophageal reflux","volume":"2014","author":"Tighe M","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"23","key":"e_1_2_10_5_1","first-page":"3082","article-title":"Treatment of gastroesophageal reflux disease","volume":"127","author":"Essilfie I","year":"2007","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_10_6_1","unstructured":"Norsk barnelegeforening Generell veileder i Pediatri.Helicobacter pylori.2022. 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