{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:11:34Z","timestamp":1785499894032,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["CDA2018\u2010008"],"award-info":[{"award-number":["CDA2018\u2010008"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014364","name":"National Children's Research Centre","doi-asserted-by":"publisher","award":["D\/18\/6"],"award-info":[{"award-number":["D\/18\/6"]}],"id":[{"id":"10.13039\/100014364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe early cerebral oxygenation (cSO<jats:sub>2<\/jats:sub>) and fractional tissue oxygen extraction (FTOE) values and their evolution over the first days of life in infants with all grades of hypoxic\u2010ischaemic encephalopathy (HIE) and to determine whether cSO<jats:sub>2<\/jats:sub> and FTOE measured early (6 and 12\u2009h) can predict short\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, observational study of cerebral near\u2010infrared spectroscopy (NIRS) in infants &gt;36\u2009weeks' gestation with HIE. Ten one\u2010hour epochs of cSO<jats:sub>2<\/jats:sub> and FTOE were extracted for each infant over the first 84\u2009h. Infants with moderate and severe HIE received therapeutic hypothermia (TH). Abnormal outcome was defined as abnormal magnetic resonance imaging (MRI) and\/or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight infants were included (28 mild, 24 moderate, 6 severe). Median gestational age was 39.9\u2009weeks (IQR 38.1\u201340.7) and birthweight was 3.35\u2009kgs (IQR 2.97\u20133.71). cSO<jats:sub>2<\/jats:sub> increased and FTOE decreased over the first 24\u2009h in all grades of HIE. Compared to the moderate group, infants with mild HIE had significantly higher cSO<jats:sub>2<\/jats:sub> at 6\u2009h (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), 9\u2009h (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) and 12\u2009h (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032) and lower FTOE at 6\u2009h (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) and 9\u2009h (0.029). cSO<jats:sub>2<\/jats:sub> and FTOE at 6 and 12\u2009h did not predict abnormal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants with mild HIE have higher cSO<jats:sub>2<\/jats:sub> and lower FTOE than those with moderate or severe HIE in the first 12\u2009h of life. cSO<jats:sub>2<\/jats:sub> increased in all grades of HIE over the first 24\u2009h regardless of TH status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16493","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:54:47Z","timestamp":1658566487000},"page":"1870-1877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evolution of early cerebral <scp>NIRS<\/scp> in hypoxic ischaemic encephalopathy"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-3246","authenticated-orcid":false,"given":"Aisling A.","family":"Garvey","sequence":"first","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Radiology Cork University Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea M.","family":"Pavel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Panaite","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Anne","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene M.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Child Health University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Neonatology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.02.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151642"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.10.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.84"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.07.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518687"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.051"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.164"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"issue":"1","key":"e_1_2_10_13_1","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich AJ","year":"1998","journal-title":"AJNR"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353948"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14972"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315744094"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00179.x"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"339","article-title":"Cerebral, renal, and splanchnic tissue oxygen saturation values in healthy term newborns","volume":"31","author":"Bailey SM","year":"2014","journal-title":"Am J Perinatol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.110"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2708"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.166983"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.2.F110"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60837-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11551.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.072"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.154"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1955"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/children7110209"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.042"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101273"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.16493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:06:45Z","timestamp":1737173205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/apa.16493"],"URL":"https:\/\/doi.org\/10.1111\/apa.16493","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"2022-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}