{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:20:23Z","timestamp":1792225223504,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The primary aim was to estimate premature infants' spontaneous patent ductus arteriosus closure rate. Secondly, to identify criteria associated with the chance of spontaneous closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of 167 infants born before 32\u2009weeks of gestation and diagnosed with a patent ductus arteriosus between 1 January 2008 and 31 December 2017. The spontaneous patent ductus arteriosus closure event rate was evaluated using the Kaplan\u2013Meier estimator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The spontaneous closure rate within the first year of life was 66% (95% CI 58%\u201373%), increasing to 80% (95% CI 72%\u201386%) five years after birth. When including both spontaneous closure and closure following treatment, 96% (95% CI 86%\u2013100%) closed within 5\u2009years after birth. The chance of spontaneous closure was reduced in the case of a large patent ductus arteriosus: OR 0.16 (95% CI 0.05\u20130.52), left atrial enlargement: OR 0.16 (95% CI 0.05\u20130.51), and pulmonary hypertension: OR 0.23 (95% CI 0.07\u20130.74).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The chance of spontaneous closure in premature infants born between 23 and 32\u2009weeks of gestation was high, and the incidence continued increasing until 5\u2009years of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16541","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T15:19:10Z","timestamp":1663082350000},"page":"2322-2330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The chance of spontaneous patent ductus arteriosus closure in preterm infants born before 32\u2009weeks of gestation is high and continues to increase until 5\u2009years of follow\u2010up"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-6864","authenticated-orcid":false,"given":"Mette R\u00f8nn","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elisabet","family":"Aldenryd","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Hagstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Mendes","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninna","family":"Brix","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2418"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200502000-00019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.03.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3730"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.10.1030"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31815ed059"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951118000641"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.166"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306339"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-4258"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000454798"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000200"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-0903(03)00143-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2019.12.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.129270"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.07.035"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.032"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1209"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.04.010"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.02.006"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.05.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.12.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.02.046"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313880"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0372"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02584.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.91"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821b1f10"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-016-0552-7"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.16541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T14:09:42Z","timestamp":1693663782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/apa.16541"],"URL":"https:\/\/doi.org\/10.1111\/apa.16541","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]},"assertion":[{"value":"2022-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}