{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:42:28Z","timestamp":1747183348144,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The full blood count (FBC) is commonly measured as part of a partial septic work\u2010up in asymptomatic infants at increased risk of early\u2010onset neonatal sepsis (EOS). To determine the impact of FBC parameters on infants' subsequent management a retrospective cross\u2010sectional study was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants, born at \u226534\u2009weeks gestation, asymptomatic at birth, undergoing a partial septic work\u2010up and receiving prophylactic antibiotics due to increased risk of EOS in a single centre over a 2\u2010year period, were included. The primary outcome measure was frequency of FBC result impacting on duration of antibiotic therapy. Secondary outcome measures included frequency of FBC parameters outside of the reference range and incidental diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 16\u2009726 live\u2010born infants were delivered during the study period. A total of 802 (4.8%) were included. Thirteen infants (1.6%) received a prolonged course of antibiotics due to suspicion for EOS. Two of these infants had elevated white cell counts. All had normal neutrophil counts. In no case did the FBC result influence the decision to prolong the antibiotic course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a cohort of 802 infants, asymptomatic at birth and at increased risk of EOS, the FBC result did not impact on the decision to prolong the course of antibiotics for suspicion of EOS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16602","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:24:04Z","timestamp":1669296244000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The full blood count in screening asymptomatic infants for early\u2010onset sepsis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-7464","authenticated-orcid":false,"given":"John","family":"Coveney","sequence":"first","affiliation":[{"name":"Department of Neonatology Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"O'Loughlin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Rotunda Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionnuala N\u00ed","family":"Ainle","sequence":"additional","affiliation":[{"name":"Department of Haematology Rotunda Hospital  Dublin Ireland"},{"name":"School of Medicine University College Dublin (UCD)  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Drew","sequence":"additional","affiliation":[{"name":"Clinical Innovation Unit Rotunda Hospital  Dublin Ireland"},{"name":"Irish Meningitis and Sepsis Reference Laboratory Children's Health Ireland  Dublin Ireland"},{"name":"Department of Clinical Microbiology Royal college of Surgeons  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-7653","authenticated-orcid":false,"given":"Michael A.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Neonatology Rotunda Hospital  Dublin Ireland"},{"name":"Department of Neonatology Children's Health Ireland  Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0B013E318223BAD2"},{"key":"e_1_2_11_3_1","first-page":"467","article-title":"Neonatal Bacteraemia among 112,360 live births","volume":"109","author":"Huggard D","year":"2016","journal-title":"Ir Med J"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.299.17.2056"},{"key":"e_1_2_11_6_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease: revised guidelines from CDC","volume":"59","author":"Verani JR","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.2019-2350"},{"key":"e_1_2_11_8_1","unstructured":"National Institute for Clinical Excellence.Neonatal infection: antibiotics for prevention and treatment. 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