{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:07:55Z","timestamp":1767848875758,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["426498"],"award-info":[{"award-number":["426498"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 2009432"],"award-info":[{"award-number":["GNT 2009432"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta\u2010analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta\u2010analysis before their results are known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore whether high (60%) or low (30%) oxygen is associated with greater efficacy and safety for the initial resuscitation (immediately after birth) of preterm infants born at &lt;29\u2009weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We will conduct a prospective meta\u2010analysis (PMA) with individual participant data (IPD). We will perform a systematic search to identify ongoing RCTs including infants &lt;29\u2009weeks' gestation randomised to high (60%) or low (30%) oxygen for initial resuscitation after birth. IPD will be sought for all infants randomised for the purpose of meta\u2010analysis. We will employ a one\u2010stage random\u2010effects approach to IPD meta\u2010analysis. Potential heterogeneity and the differential effect of high or low oxygen will be explored through subgroup and interaction analyses. The primary outcome of this study is all\u2010cause mortality prior to hospital discharge. There will be a follow\u2010up analysis of neurodevelopmental outcomes once available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/Conclusion<\/jats:title><jats:p>The results of neonatal outcomes at hospital discharge are expected by 2025, and neurodevelopmental outcomes by 2027.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16622","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T14:23:45Z","timestamp":1670595825000},"page":"372-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PROspective<\/scp> Meta\u2010analysis Of Trials of Initial Oxygen in preterm Newborns (<scp>PROMOTION<\/scp>): Protocol for a systematic review and prospective meta\u2010analysis with individual participant data on initial oxygen concentration for\u00a0resuscitation of preterm infants"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-5647","authenticated-orcid":false,"given":"James X.","family":"Sotiropoulos","sequence":"first","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"},{"name":"School of Women's and Children's Health, Faculty of Medicine and Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation, Neonatology Royal Alexandra Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-3771","authenticated-orcid":false,"given":"Ju Lee","family":"Oei","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, Faculty of Medicine and Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol","family":"Libesman","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2796-9220","authenticated-orcid":false,"given":"Kylie E.","family":"Hunter","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-0999","authenticated-orcid":false,"given":"Jonathan G.","family":"Williams","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Webster","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William O.","family":"Tarnow\u2010Mordi","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health University of Sydney  Camperdown New South Wales 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