{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:33:37Z","timestamp":1784957617665,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess safety of COVID\u201019 vaccination in paediatric patients with immune\u2010mediated inflammatory disease (IMID).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects of 5\u201321\u2009years of age with IMID who received at least one COVID\u201019 vaccine completed electronic surveys after each vaccine to assess side effects within 1\u2009week of vaccination, current medications and COVID\u201019 testing after vaccination. Charts were reviewed for COVID\u201019 polymerase chain reaction and IgG response to SARS\u2010CoV\u20102 spike protein results and for disease flare during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 190 enrolled subjects, 71% were female, with median age 17 (range 6\u201321) years. The most common diagnosis was juvenile idiopathic arthritis\/rheumatoid arthritis (55%). 78% of subjects were taking immunosuppressive medication. At least one side effect was reported in 65% of subjects after any dose of the vaccine; with side effects in 38%, 53% and 55% of subjects after the first, second and third vaccine doses, respectively. The most common side effects were injection site pain (59%), fatigue (54%) and headache (39%). No anaphylaxis or myocarditis was reported. Three subjects (2%) experienced disease flare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort of paediatric patients with IMID, observed side effects were found to be mild and disease flare rates were found to be low following COVID\u201019 vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16652","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T13:34:16Z","timestamp":1672407256000},"page":"794-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The safety of COVID\u201019 vaccination in immunocompromised children and young adults with immune\u2010mediated inflammatory disease"],"prefix":"10.1111","volume":"112","author":[{"given":"Benjamin","family":"Sahn","sequence":"first","affiliation":[{"name":"Department of Pediatrics Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  New Hyde Park New\u00a0York 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