{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:22:25Z","timestamp":1791915745910,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse the epidemiology of intussusception in Hokkaido Prefecture, Japan during a 10\u2010year period spanning the introduction of the rotavirus (RV) vaccine (2007\u20132016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a standard questionnaire, a retrospective surveillance was conducted across 17 hospitals with paediatric beds in Hokkaido Prefecture. We compared the data between the pre\u2010vaccine era (2007\u20132011) and post\u2010vaccine era (2012\u20132016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 208 and 110 intussusception cases were in the pre\u2010 and post\u2010vaccine eras, respectively. A significant reduction of the intussusception incidence in children aged\u2009&lt;1\u2009year was observed from the pre\u2010 to the post\u2010vaccine era (102.4\u201356.5 per 100\u2009000 infants; incidence rate ratio, 0.55; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). There was a relatively high\u2010positive RV antigen detection rate (29.4%, 5\/17) during the RV epidemic period in Japan (March\u2013May) in the pre\u2010vaccine era. None of the intussusception cases in the 31 patients with a history of RV vaccination occurred within 1\u2009month after the administration of an RV vaccine dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of intussusception in children aged\u2009&lt;1\u2009year decreased significantly after RV vaccine introduction in Japan. Another survey is needed to determine how the incidence of intussusception has changed further since the introduction of routine RV vaccination in 2020.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16656","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T15:02:04Z","timestamp":1672930924000},"page":"868-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of intussusception among children in Hokkaido, Japan, during the pre\u2010 and post\u2010rotavirus vaccine eras (2007\u20132016)"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-7224","authenticated-orcid":false,"given":"Yuya","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Akane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saho","family":"Honjo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-3000","authenticated-orcid":false,"given":"Takeshi","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068482"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03622_1.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268805004644"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.65.301"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-36"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2021.04.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200102223440804"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200104000-00008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.6.e67"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa052434"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa052664"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1311738"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1303164"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1012952"},{"issue":"5","key":"e_1_2_12_16_1","first-page":"49","article-title":"Rotavirus vaccines. 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