{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:02:02Z","timestamp":1787583722565,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010983","name":"Health Research Fund of Central Denmark Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We aimed to improve bone health management of children with cerebral palsy (CP) by reviewing studies investigating bisphosphonate therapy in children with CP and other types of secondary osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included trials on bisphosphonate treatment reporting any direct bone measurement or fracture outcome. All studies of patients with CP were included. We also included all controlled trials of children with secondary bone fragility as well as observational studies with \u226520 participants or at least 3\u2009years of follow\u2010up. Studies were assessed according to PRISMA guidelines using the RoB2\u2010tool and the Newcastle\u2010Ottawa Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We reviewed 1104 studies and found 37 eligible. Some studies were sufficiently homogeneous to include in a meta\u2010analysis, and we found a 1\u2010year effect on lumbar spine bone mineral density (BMD) Z\u2010score of +0.65 after oral and\u2009+\u20091.21 after intravenous bisphosphonates in children with secondary osteoporosis. Further, data on adverse events and post\u2010treatment follow\u2010up were reviewed. Limitations were heterogeneity and small size of the included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Meta\u2010analysis consistently showed significant BMD increases with bisphosphonates in children with secondary osteoporosis. Direct evidence of the effect of bisphosphonates on reducing fractures is lacking. We found no reports of long\u2010term adverse events yet longer studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.16671","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:39:06Z","timestamp":1673843946000},"page":"617-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cerebral palsy and bisphosphonates \u2013 and what can be learned from other types of secondary osteoporosis in children: A scoping review"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-6759","authenticated-orcid":false,"given":"Jakob B.","family":"Granild\u2010Jensen","sequence":"first","affiliation":[{"name":"Department of Child and Youth Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line K.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department 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