{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:14:49Z","timestamp":1777558489299,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate closed\u2010loop automated oxygen control (CLAC) in ventilated infants &gt;33\u2009weeks of gestation with different respiratory disease severities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care or standard care with CLAC (Oxygenie) first. Analyses were performed of the results of infants with or without an FiO<jats:sub>2<\/jats:sub>\u2009\u2265\u20090.3 and infants with congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one infants with a median (IQR) gestational age of 37.9 (37.1\u201338.9) weeks were studied at a median postmenstrual age (IQR) of 38.9 (37.4\u201339.8) weeks. In infants with an FiO<jats:sub>2<\/jats:sub>\u2009\u2265\u20090.3 (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), CLAC increased the time spent in target oxygen range (92\u201396%) by 61.6% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018), whereas in infants with an FiO<jats:sub>2<\/jats:sub>\u2009&lt;\u20090.3, the time in target was increased by 3.8% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.019). During CLAC, only infants with an FiO<jats:sub>2<\/jats:sub>\u2009\u2265\u20090.3 spent less time in hyperoxemia (SpO<jats:sub>2<\/jats:sub>\u2009&gt;\u200996%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and hyperoxemic episodes were shorter (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). In both groups, CLAC reduced the duration of desaturations (SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200992%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In CDH infants, CLAC increased the time spent in target oxygen range by 34% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036) and the median duration of desaturations was reduced (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CLAC may be more useful in infants with more severe respiratory distress.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16678","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T14:59:27Z","timestamp":1674140367000},"page":"1185-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Closed\u2010loop oxygen system in late preterm\/term, ventilated infants with different severities of respiratory disease"],"prefix":"10.1111","volume":"112","author":[{"given":"Ourania","family":"Kaltsogianni","sequence":"first","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"additional","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Neonatal Intensive Care Centre King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Harris","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Ann","family":"Lee","sequence":"additional","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashiro","family":"Sugino","sequence":"additional","affiliation":[{"name":"Shikoku Medical Centre for Children and Adults  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2643-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15585"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15089"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.915312"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16598"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.44"},{"issue":"4","key":"e_1_2_11_8_1","first-page":"F366","article-title":"Randomised cross\u2010over study of automated oxygen control for preterm infants receiving nasal high flow","volume":"104","author":"Reynolds PR","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.072"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0413"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02506.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.03.003"},{"issue":"12","key":"e_1_2_11_13_1","first-page":"846","article-title":"Antioxidant profiles in full term and preterm neonates","volume":"28","author":"Lee YS","year":"2005","journal-title":"Chang Gung Med J"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121879"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.808317"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.09.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-017-0031-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181bab0c7"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.16678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:43:50Z","timestamp":1694713430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/apa.16678"],"URL":"https:\/\/doi.org\/10.1111\/apa.16678","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"2022-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}