{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:16Z","timestamp":1747183216991,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the predictive ability of prolonged requirements for mechanical ventilation or tube feeding support for 18\u2010month composite outcomes in infants with hypoxic\u2010ischaemic encephalopathy treated with hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, nationwide, observational study focused on newborn infants registered in Japan's Baby Cooling Registry between 1 January 2012 and 31 December 2016. The adverse outcomes were defined as death or survival with cerebral palsy, visual or auditory impairment or the requirement for mechanical ventilation or tube feeding at 18\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adverse outcomes occurred in 165 (28%) of the 591 children in the final cohort. These were predicted by prolonged dependence on mechanical ventilation or tube feeding for more than seven and more than 14\u2009days. The respective values were positive predictive value 0.34 (95% CI 0.33\u20130.34) and 0.60 (95% CI 0.56\u20130.62), negative predictive value 0.97 (95% CI 0.91\u20130.99) and 0.93 (95% CI 0.90\u20130.95) and area under the curve 0.59 (95% CI 0.54\u20130.64) and 0.81 (95% CI 0.77\u20130.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prolonged dependence on mechanical ventilation or tube feeding for more than 14\u2009days may be useful in predicting 18\u2010month outcomes in newborn infants who have received therapeutic hypothermia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16687","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:39:15Z","timestamp":1674891555000},"page":"734-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged requirements for mechanical ventilation and tube feeding support predicted 18\u2010month outcomes for neonatal encephalopathy"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-5260","authenticated-orcid":false,"given":"Kennosuke","family":"Tsuda","sequence":"first","affiliation":[{"name":"Center for Human Development and Family Science, Department of Neonatology and Pediatrics Nagoya City University Graduate School of Medical Sciences  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-4697","authenticated-orcid":false,"given":"Jun","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-4075","authenticated-orcid":false,"given":"Akihito","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Neonatology National Hospital Organization Okayama Medical Center  Okayama 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