{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:02:42Z","timestamp":1749182562451,"version":"3.41.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Temporal changes in common pathogens that cause clinical dysentery have been described in Europe. We aimed to describe the distribution of pathogens and their antibiotic resistance in hospitalised Israeli children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively studied children hospitalised for clinical dysentery, with or without a positive stool culture, from 1 January 2016 to 31 December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We diagnosed 137 patients (65% males), with clinical dysentery at a median age of 3.7 (interquartile range 1.5\u20138.2) years. Stools were cultured in 135 patients (99%), and the results were positive in 101 (76%). These comprised <jats:italic>Campylobacter<\/jats:italic> (44%), <jats:italic>Shigella sonnei<\/jats:italic> (27%), non\u2010typhoid <jats:italic>Salmonella<\/jats:italic> (18%) and <jats:italic>enteropathogenic Escherichia coli<\/jats:italic> (12%). Only one of the 44 <jats:italic>Campylobacter<\/jats:italic> cultures was resistant to erythromycin and one of the 12 <jats:italic>enteropathogenic Escherichia coli<\/jats:italic> cultures was resistant to ceftriaxone. None of the <jats:italic>Salmonella<\/jats:italic> and <jats:italic>Shigella<\/jats:italic> cultures were resistant to ceftriaxone or erythromycin. We did not find any pathogens that were associated with a typical clinical presentation or laboratory results on admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most common pathogen was <jats:italic>Campylobacter<\/jats:italic>, in line with recent European trends. Bacterial resistance for commonly prescribed antibiotics was rare, and these findings support the current European recommendations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16717","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:47:04Z","timestamp":1676746024000},"page":"1067-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacterial resistance to commonly prescribed antibiotics was rare among children hospitalised for clinical dysentery"],"prefix":"10.1111","volume":"112","author":[{"given":"Regina","family":"Goldshtein","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Laniado Hospital  Netanya Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nechama","family":"Sharon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Laniado Hospital  Netanya Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Yana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Laniado Hospital  Netanya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Laniado Hospital  Netanya Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2231-4209","authenticated-orcid":false,"given":"Achiya Z.","family":"Amir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Laniado Hospital  Netanya Israel"},{"name":"Institute of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Dana\u2010Dwek Children's Hospital, Tel\u2010Aviv Medical Center Affiliated to Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.The Treatment of Diarrhea\u2010 A manual for physicians and other senior health workers.2005. Accessed January 31st 2023.https:\/\/apps.who.int\/iris\/rest\/bitstreams\/51268\/retrieve"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000375"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000768"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2017.1409454"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2494"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31826df662"},{"volume-title":"Antibiotic Resistance Threats in the United States, 2019","year":"2019","author":"CDC","key":"e_1_2_9_9_1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199402000-00008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-002-2166-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880900243X"},{"key":"e_1_2_9_13_1","unstructured":"DayanN RevivoD EvenL et al.Campylobacter is the leading cause of bacterial gastroenteritis and dysentery among hospitalized children in the Western Galilee area. Paper presented at: 2010 Israeli Clinical Pediatrics Society Conference Tel Aviv 3 February 2010. 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