{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:07Z","timestamp":1787773027783,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["733001"],"award-info":[{"award-number":["733001"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Children with congenital anomalies often require surgery but data on the burden of surgery for these children are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based record\u2010linkage study in Finland, Wales and regions of Denmark, England, Italy and Spain. A total of 91\u2009504 children with congenital anomalies born in 1995\u20132014 were followed to their tenth birthday or the end of 2015. Electronic linkage to hospital databases provided data on inpatient surgical procedures and meta\u2010analyses of surgical procedures were performed by age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of children having surgery in the first year was 38% with some differences across regions and 14% also underwent surgery at age 1\u20134\u2009years. Regional differences in age at the time of their first surgical procedure were observed for children with cleft palate, hydronephrosis, hypospadias, clubfoot and craniosynostosis. The children had a median of 2.0 (95% CI 1.98, 2.02) surgical procedures before age 5\u2009years with children with oesophageal atresia having the highest median number of procedures (4.5; 95% CI 3.3, 5.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A third of children with congenital anomalies required surgery during infancy and often more than one procedure was needed before age 5\u2009years. There was no European consensus on the preferred age for surgery for some anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16726","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T04:42:00Z","timestamp":1677213720000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["European study showed that children with congenital anomalies often underwent multiple surgical procedures at different ages across Europe"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-2594","authenticated-orcid":false,"given":"Ester","family":"Garne","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital University Hospital of Southern Denmark  Kolding 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