{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:37:58Z","timestamp":1774723078701,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the safety and efficacy of long\u2010term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre retrospective study of all children \u226418\u2009years with acute decompensated heart failure and DCM who received continuous long\u2010term (\u22657 consecutive days) intravenous milrinone between January 2008 and January 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 47 patients had a median age of 3.3\u2009months [interquartile range (IQR) 1.0\u201318.1], weight of 5.7\u00a0kg [IQR 4.3\u201310.1] and fractional shortening of 11.9% [\u00b14.7]. Idiopathic DCM (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) and myocarditis (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) were the most common diagnoses. The median milrinone infusion duration was 27\u2009days [IQR 10\u201350, range 7\u2013290]. No adverse events necessitated milrinone termination. Nine patients required mechanical circulatory support. Median follow\u2010up was 4.2\u2009years [IQR 2.7\u20138.6]. On initial admission, four patients died, six were transplanted and 79% [37\/47] were discharged home. The 18 readmissions resulted in five more deaths and four transplantations. Cardiac function recovered in 60% [28\/47], as measured by normalised fractional shortening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term intravenous milrinone is safe and effective in paediatric acute decompensated DCM. Combined with conventional heart failure therapies, it can act as a bridge to recovery and thereby potentially reduce the need for mechanical support or heart transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16738","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T13:58:13Z","timestamp":1677851893000},"page":"1298-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term milrinone therapy in children with dilated cardiomyopathy"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-1251","authenticated-orcid":false,"given":"Samuel","family":"Brown","sequence":"first","affiliation":[{"name":"Medical School, College of Medical and Dental Sciences University of Birmingham  Birmingham 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