{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:58:32Z","timestamp":1783101512596,"version":"3.54.6"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the outcomes of very preterm infants with hyperglycaemia treated with Insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a systematic review of randomised controlled trials (RCTs) and observational studies. PubMed, Medline, EMBASE, Cochrane Library, EMCARE and MedNar databases were searched in May 2022. Data were pooled separately for adjusted and unadjusted odds ratios (ORs) using random\u2010effects model. Main outcome measures: Mortality and morbidities (e.g. Necrotising enterocolitis [NEC], retinopathy of prematurity [ROP]) in very preterm (&lt;32\u2009weeks) or very low birth weight infants (&lt;1500\u2009g) after treatment of hyperglycaemia with insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies with data from 5482 infants were included. Meta\u2010analysis of unadjusted ORs from cohort studies showed that insulin treatment was significantly associated with increased mortality [OR 2.98 CI (1.03 to 8.58)], severe ROP [OR 2.23 CI (1.34 to 3.72)] and NEC [OR 2.19 CI (1.11 to 4)]. However, pooling of adjusted ORs did not show significant associations for any outcomes. The only included RCT found better weight gain in the insulin group, but no effect on mortality or morbidities. Certainty of evidence was \u2018Low\u2019 or \u2018Very low\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Very low certainty evidence suggests that Insulin therapy may not improve outcomes of very preterm infants with hyperglycaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16748","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T05:18:22Z","timestamp":1678425502000},"page":"1157-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of very preterm infants with hyperglycaemia treated with insulin: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"112","author":[{"given":"Nital","family":"Patidar","sequence":"first","affiliation":[{"name":"Paediatrics Armadale General Hospital  Armadale Western Australia 6112 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-1996","authenticated-orcid":false,"given":"Chandra Prakash","family":"Rath","sequence":"additional","affiliation":[{"name":"Neonatalogy King Edward Memorial Hospital  Subiaco Western Australia 6008 Australia"},{"name":"Neonatal Perth Children's Hospital  Nedland Western Australia 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shripada","family":"Rao","sequence":"additional","affiliation":[{"name":"Neonatal Perth Children's Hospital  Nedland Western Australia 6009 Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patole","sequence":"additional","affiliation":[{"name":"Neonatalogy King Edward Memorial Hospital  Subiaco Western Australia 6008 Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.537"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014027"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000160"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0644-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90167-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-321449"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079545"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21926\/obm.neurobiol.1903038"},{"issue":"10","key":"e_1_2_11_10_1","article-title":"Interventions for treatment of neonatal hyperglycemia in very low birth weight infants","author":"Bottino M","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.27.2.127"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.132.4.631"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(03)00123-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1667"},{"key":"e_1_2_11_16_1","unstructured":"WellsGA SheaB\u2010J O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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