{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:08:06Z","timestamp":1790104086919,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the risk of developing adolescent scoliosis among recipients of recombinant human growth hormone (rhGH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This registry\u2010based cohort study included 1314 individuals who initiated rhGH treatment since 2013, treated during 10\u201318\u2009years of age for at least 6\u2009months. This group was matched to a comparison group of 6570 individuals not treated with rhGH. Demographic and clinical information was extracted from the electronic database. The results are presented using hazard ratios (HR) and 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 4.2\u2009years, 59 (4.5%) rhGH recipients and 141 individuals (2.1%) from the comparison group were diagnosed with adolescent scoliosis. The age at diagnosis did not differ between the groups (14.7 versus 14.3\u2009years, <jats:italic>p<\/jats:italic>\u00a0=\u20090.095). Patients treated with rhGH were more likely diagnosed with scoliosis (HR 2.12, 95% CI 1.55\u20132.88, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Among males, the risk was about three times greater in the treated versus the comparison group (HR 3.15, 95% CI 2.12\u20134.68, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), while in females the risk was not increased (HR 1.12, 95% CI 0.72\u20132.04, <jats:italic>p<\/jats:italic>\u00a0=\u20090.469).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recombinant human growth hormone treatment was associated with an increased risk to be diagnosed with adolescent scoliosis in males. Scoliosis development should be monitored appropriately in rhGH recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16749","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T05:20:25Z","timestamp":1678425625000},"page":"1240-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Growth hormone treatment and the risk of adolescent scoliosis: A large matched cohort study"],"prefix":"10.1111","volume":"112","author":[{"given":"Tomer","family":"Ziv\u2010Baran","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine, School of Public Health Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalit","family":"Modan\u2010Moses","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine University of Tel Aviv  Tel Aviv Israel"},{"name":"Meuhedet Health Services  Tel Aviv Israel"},{"name":"Pediatric Endocrinology and Diabetes Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Zacay","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine University of Tel Aviv  Tel Aviv Israel"},{"name":"Meuhedet Health Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissim","family":"Ackshota","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine University of Tel Aviv  Tel Aviv Israel"},{"name":"Department of Pediatric Orthopedics The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-4230","authenticated-orcid":false,"given":"Yael","family":"Levy\u2010Shraga","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine 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