{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:16:13Z","timestamp":1776903373664,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to describe amplitude integrated electroencephalography (aEEG) cyclicity, background pattern, voltage margins and maturation scores in extremely low gestational age neonates (ELGANs) in the first 72\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty infants with gestational age (GA) 23+0\u201327+6\u2009weeks were prospectively studied. Infants with intraventricular haemorrhage \u2266 Grade I and no disorders of transition (persistent pulmonary hypertension, hypotension, pulmonary haemorrhage) belonged to the \u2018Uncomplicated\u2019 group and those with intraventricular haemorrhage &gt; Grade I and\/or disorders of transition, to the \u2018Complicated\u2019 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six infants without opioid exposure were included: 23 with GA 25.9 (23.1\u201327.7) weeks in the \u2018Uncomplicated\u2019 group and 13 with GA 24.6 (23.3\u201327.4) weeks in the \u2018Complicated\u2019 group. Cyclicity was more common in the \u2018Uncomplicated\u2019 group [20\/23 (87%) vs. 7\/13 (54%), <jats:italic>p<\/jats:italic>\u2009=\u20090.045] with more cycles\/hour [0.2 (0\u20130.78) vs. 0.03 (0\u201367), <jats:italic>p<\/jats:italic>\u2009=\u20090.036]. Age at appearance of cyclicity was similar [20 (7.7\u201340.7) hours in \u2018Uncomplicated\u2019 vs. 23.7 (5.4\u201360) hours in \u2018Complicated\u2019 group, <jats:italic>p<\/jats:italic>\u2009=\u20090.8]. In the \u2018Uncomplicated\u2019 group, maturation scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), high (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and low (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) base voltage increased over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During the first 72\u2009h, clinically stable ELGANs without neurological injury demonstrate increased cyclicity compared to those with a complicated course. Maturation score, high and low base voltage increase over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16761","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:46:11Z","timestamp":1679305571000},"page":"1213-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trends in cyclicity and amplitudes on amplitude\u2010integrated electroencephalography during transition in extremely low gestational age infants"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7228-0118","authenticated-orcid":false,"given":"Poorva","family":"Deshpande","sequence":"first","affiliation":[{"name":"Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Division of Neonatology University of Toronto  Toronto Ontario 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