{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:27Z","timestamp":1747183227414,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Whereas there is agreement that surfactant should be administered without mechanical ventilation, there is still a debate concerning the optimal method. DD\u2010SURF combines the benefits of INSURE and less invasive surfactant administration (LISA). The efficacy of this approach has not been evaluated yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of all preterm newborns below 30<jats:sup>0\/7<\/jats:sup> weeks gestational age admitted to the neonatal intensive care unit. Data on surfactant therapy, respiratory support during the first 96\u2009h of life and neonatal morbidities until hospital discharge were collected from the electronic patient charts to evaluate the efficacy and safety of our approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 222 newborns met the inclusion criteria; 174 (78%) received surfactant in the delivery room by the DD\u2010SURF procedure and 21 infants (10%) were not extubated after surfactant administration (Surf\u2010and\u2010vent group). After DD\u2010SURF, 75% of patients did not require reintubation. Intraventricular haemorrhage and bronchopulmonary dysplasia occured more often in infants after DD\u2010SURF failure than after successful DD\u2010SURF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DD\u2010SURF potentially combines the benefits of INSURE and LISA and represents a useful alternative of surfactant delivery with comparable success rates to thin\u2010catheter surfactant administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16767","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:39:45Z","timestamp":1679481585000},"page":"1653-1658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surfactant administration during endotracheal <scp>CPAP<\/scp>: Feasibility, risk factors for failure and short\u2010term outcomes of <scp>DD\u2010SURF<\/scp>"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-8987","authenticated-orcid":false,"given":"Lars","family":"Mense","sequence":"first","affiliation":[{"name":"Division of Neonatology &amp; 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Pediatric Intensive Care Medicine, Department of Pediatrics University Hospital Carl Gustav Carus Dresden TU Dresden  Dresden Germany"},{"name":"Saxony Center for Feto\/Neonatal Health TU Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-1209","authenticated-orcid":false,"given":"Mario","family":"R\u00fcdiger","sequence":"additional","affiliation":[{"name":"Division of Neonatology &amp; Pediatric Intensive Care Medicine, Department of Pediatrics University Hospital Carl Gustav Carus Dresden TU Dresden  Dresden Germany"},{"name":"Saxony Center for Feto\/Neonatal Health TU Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"CD000141","article-title":"Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome","volume":"21","author":"Soll R","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"HobarJD SollRF SutherlandJM et al.A multicenter randomized placebo\u2010controlled trial of surfactant therapy for respiratory distress syndrome.2010;320(15):959\u2010965. doi:10.1056\/NEJM198904133201502","DOI":"10.1056\/NEJM198904133201502"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","unstructured":"MorleyCJ DavisPG DoyleLW BrionLP HascoetJM CarlinJB.Nasal CPAP or intubation at birth for very preterm infants.2009;358(7):700\u2010708. doi:10.1056\/NEJMOA072788","DOI":"10.1056\/NEJMoa072788"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.2009-2131"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00134-001-1117-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003063.pub3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101230"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0504"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301314"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011672.pub2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0642-0614"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.21892"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25798"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337346"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-017-0009-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30405-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13850"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:45:11Z","timestamp":1692218711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/apa.16767"],"URL":"https:\/\/doi.org\/10.1111\/apa.16767","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"2023-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}