{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:30:22Z","timestamp":1788240622928,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal bile acid pneumonia (NBAP) occurs in neonates following obstetric cholestasis. We aimed to study the lung aeration and respiratory support of NBAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nested, case\/control study enrolling age\u2010matched neonates with NBAP, respiratory distress syndrome (RDS) or transient tachypnoea (TTN). Lung aeration and oxygenation were assessed with lung ultrasound score, oxygenation index and SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen, 22 and 25 neonates with NBAP, RDS and TTN, respectively were studied (mean gestational age = 33 (2.2) weeks, 30 (45.5%) males). Upon admission, RDS patients had the worst lung ultrasound score (<jats:italic>p<\/jats:italic>\u2009=\u20090.022) and oxygenation index (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), while NBAP and TTN neonates had similar values. At the worst time\u2010point, NBAP and RDS patients showed similar oxygenation index (NBAP: 4.6 [2], RDS: 5.7 [3]) and SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (NBAP: 3.1 [1.1], RDS: 2.7 [1]) which were worse than those of TTN patients (oxygenation index: <jats:italic>p<\/jats:italic>\u2009=\u20090.015, SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>: <jats:italic>p<\/jats:italic>\u2009=\u20090.001). RDS neonates needed the longest continuous positive airway pressure and highest mean airway pressure, but NBAP neonates needed invasive ventilation (26.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and surfactant (31.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) more often than TTN patients who never needed these.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NBAP was a mild disorder in the first hours of life but subsequently worsened and became similar to RDS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16865","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T15:19:07Z","timestamp":1685719147000},"page":"1898-1904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasound\u2010assessed lung aeration, oxygenation and respiratory care in neonatal bile acid pneumonia: A nested case\u2013control study"],"prefix":"10.1111","volume":"112","author":[{"given":"Giulia","family":"Regiroli","sequence":"first","affiliation":[{"name":"Division of Paediatrics and Neonatal Critical Care, \u201cA.Beclere\u201d Medical Centre Paris Saclay University Hospitals, APHP  Paris France"},{"name":"Physiopathology and Therapeutic Innovation Unit\u2010INSERM U999 Paris Saclay University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"La\u00a0Malfa","sequence":"additional","affiliation":[{"name":"Division of Paediatrics and Neonatal Critical Care, \u201cA.Beclere\u201d Medical Centre Paris Saclay University Hospitals, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Loi","sequence":"additional","affiliation":[{"name":"Division of Paediatrics and Neonatal Critical Care, \u201cA.Beclere\u201d Medical Centre Paris Saclay University Hospitals, APHP  Paris France"},{"name":"Physiopathology and 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