{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:32Z","timestamp":1787013872678,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the prevalence, severity, risk factors, and clinical relevance of electrolyte disturbances and acute kidney injury (AKI) during febrile urinary tract infection (fUTI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational study of well\/fair\u2010appearing patients between 2\u2009months and 16\u2009years, with no previous relevant medical history, diagnosed with fUTI in the paediatric emergency department (PED) with subsequent microbiological confirmation. Analytical alteration (AA) data were considered: AKI (creatinine elevation\u2009\u00d7\u20091.5 the median for age), plasma sodium alteration (\u2264130 or \u2265150\u2009mEq\/L), and potassium alteration (\u22643 or \u22656\u2009mEq\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 590 patients, 17.8% presented AA (13 hyponatremia, 7 hyperkalaemia, and 87 AKI). No patient presented severe analytic alterations or a higher frequency of symptoms potentially attributable to these alterations (seizures, irritability, or lethargy). Risk factors associated with these AA were clinical dehydration (OR\u2009=\u20093.5 95% CI: 1.04\u201311.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and presenting a temperature &gt;39\u00b0C (OR\u2009=\u20091.9 95% CI: 1.14\u20133.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Electrolyte and renal function disturbances are infrequent in the previously healthy paediatric population with a fUTI. If present, they are asymptomatic and not severe. Based on our results, performing systematic blood analysis to rule out AA appears no longer justified, especially in the absence of risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.16881","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T08:29:59Z","timestamp":1687249799000},"page":"2202-2209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood analysis for screening of electrolyte and kidney function alterations in patients with febrile urinary tract infection"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-9143","authenticated-orcid":false,"given":"Isabel","family":"Gonz\u00e1lez\u2010Bertol\u00edn","sequence":"first","affiliation":[{"name":"Department of Pediatric Emergency La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-663X","authenticated-orcid":false,"given":"Guillermo","family":"Barbas\u00a0Bernardos","sequence":"additional","affiliation":[{"name":"Department of Urology Cl\u00ednica Universidad de Navarra  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Garc\u00eda\u00a0Suarez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology La Paz University Hospital  Madrid Spain"},{"name":"Department of Pediatric Nephrology Fuerteventura Virgen de la Pe\u00f1a General Hospital  Puerto del Rosario Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mart\u00edn\u00a0Esp\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Infanta Sof\u00eda University Hospital  San Sebasti\u00e1n de los Reyes Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-6683","authenticated-orcid":false,"given":"Cristina","family":"Barcia\u00a0Aguilar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Child Neurology Unit La Coru\u00f1a University Hospital  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"L\u00f3pez\u00a0L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-3423","authenticated-orcid":false,"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Infectious Disease La Paz University Hospital, University Autonoma of Madrid, IdiPaz Foundation, Traslational Research Network in Pediatric Infectious Diseases (RITIP), CIBERINFEC, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30676-0"},{"key":"e_1_2_9_3_1","unstructured":"Urinary tract infections in infants and children older than one month.Clinical features and diagnosis\u2014UpToDate.2020. 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