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Toll\u2010like receptors (TLR) are pattern recognition receptors known to activate innate immunity and secretion of inflammatory cytokines. Herein, we examined BT\u2010associated biomarkers and TLRs in relation to liver injury after successful portoenterostomy (SPE) in BA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum levels of lipopolysaccharide\u2010binding protein (LBP), CD14, LAL, TNF\u2010\u03b1, IL\u20106 and FABP2 along with liver expression of TLRs (<jats:italic>TLR1<\/jats:italic>, <jats:italic>TLR4<\/jats:italic>, <jats:italic>TLR7<\/jats:italic> and <jats:italic>TLR9<\/jats:italic>), <jats:italic>LBP<\/jats:italic> and <jats:italic>CD14<\/jats:italic> were measured during median 4.9 (1.7\u201310.6) years follow\u2010up after SPE in 45 BA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum LBP, CD14, TNF\u2010\u03b1 and IL\u20106 all increased after SPE whereas LAL and FABP\u20102 remained unchanged. Serum LBP correlated positively with CD14 and markers of hepatocyte injury and cholestasis, but not with Metavir fibrosis stage, transcriptional markers for fibrosis (<jats:italic>ACTA2<\/jats:italic>) or ductular reaction. Serum CD14 concentration was significantly higher in patients with portal hypertension than without. While liver expression of <jats:italic>TLR4<\/jats:italic> and <jats:italic>LBP<\/jats:italic> remained low, <jats:italic>TLR7<\/jats:italic> and <jats:italic>TLR1<\/jats:italic> showed marked BA\u2010specific increases, and <jats:italic>TLR7<\/jats:italic> correlated with Metavir fibrosis stage and <jats:italic>ACTA2<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BT does not seem to play a significant role in liver injury after SPE in our series of BA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16893","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T14:31:32Z","timestamp":1687962692000},"page":"2210-2217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bacterial translocation markers and toll\u2010like receptors in biliary atresia following successful portoenterostomy"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-3028","authenticated-orcid":false,"given":"Nimish","family":"Godbole","sequence":"first","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group and Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Kyr\u00f6nlahti","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hukkinen","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group and Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjut","family":"Pihlajoki","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Heikinheimo","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Pediatrics Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Faculty of Medicine and Health Technology, Center for Child, Adolescent, and Maternal Health Research Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko P.","family":"Pakarinen","sequence":"additional","affiliation":[{"name":"Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group and Pediatric Research Center Children's Hospital, University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Women's Health Karolinska Institute  Stockholm 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