{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:00:44Z","timestamp":1770782444363,"version":"3.50.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["190157"],"award-info":[{"award-number":["190157"]}],"id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008488","name":"Stiftelsen Alma och K. A. Snellman S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["2019"],"award-info":[{"award-number":["2019"]}],"id":[{"id":"10.13039\/501100008488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess the safety of a commonly used sedative, dexmedetomidine in neonates and infants during intensive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted in the paediatric intensive care unit at Oulu University Hospital. The study population consisted of all children from birth up to 6 months of age who received dexmedetomidine during 2010\u20132016. Adverse cardiovascular outcomes were defined as abnormal heart rates or blood pressure values according to the Paediatric Early Warning Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 172 infants, 56% had congenital malformation, and 48% had undergone surgery. Neonates and 1\u20133\u2010month\u2010olds experienced bradycardia (86% vs. 73% in 1\u20133\u2010month\u2010olds and 50% in 3\u20136\u2010month\u2010olds, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and severe bradycardia (17% vs. 14% in 1\u20133\u2010month\u2010olds and 0% in 3\u20136\u2010month\u2010olds, <jats:italic>p<\/jats:italic> =\u20090.005) more often than older patients. The median maximum rate of dexmedetomidine infusion was 0.86\u2009\u03bcg\/kg\/h (IQR\u2009=\u20090.60\u20131.71\u2009\u03bcg\/kg\/h). A dose\u2010dependent increase in bradycardia and severe hypotension was found. Adverse cardiovascular events were managed with additional fluid boluses and discontinuation of the infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adverse cardiovascular events were common during dexmedetomidine administration in neonates and infants. Lower dexmedetomidine doses may be required in sedating neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16933","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T18:04:46Z","timestamp":1690999486000},"page":"2338-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adverse cardiovascular events are common during dexmedetomidine administration in neonates and infants during intensive care"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-8684","authenticated-orcid":false,"given":"Miikka","family":"Tervonen","sequence":"first","affiliation":[{"name":"Department of Children and Adolescents Oulu University Hospital  Oulu Finland"},{"name":"PEDEGO Research Unit and Medical Research Center Oulu University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Cajanus","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-344X","authenticated-orcid":false,"given":"Merja","family":"Kallio","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents Oulu University Hospital  Oulu Finland"},{"name":"PEDEGO Research Unit and Medical Research Center Oulu University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Huhtam\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[{"name":"Department of 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