{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:33:34Z","timestamp":1783474414118,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We discuss the aetiology of recurrent abdominal pain of non\u2010organic origin, according to the Rome Criteria for Functional Gastrointestinal Disorders and a psychogenic hypothesis. Stress activates the brain\u2013gut axis, which is important for local gut symptoms, such as abdominal pain, but it also causes pain in other areas, including the head, back and chest. Our research has indicated that the startle reflex plays a dominant role in this stress\u2010induced pain pattern, which is manifested in the whole body. Localised abdominal pain can be part of a general negative stress reaction that causes multiple pains in other areas of the body.<\/jats:p>","DOI":"10.1111\/apa.16946","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T08:54:57Z","timestamp":1691744097000},"page":"2312-2316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stress and recurrent abdominal pain"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-909X","authenticated-orcid":false,"given":"G\u00f6sta","family":"Alfv\u00e9n","sequence":"first","affiliation":[{"name":"Clintec Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"},{"name":"The Swedish School of Sport and Health Sciences  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.07.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00467.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327558IJBM1002_06"},{"key":"e_1_2_6_5_1","unstructured":"LindstromA KindblomJ.Children's' experience of stress (in Swedish). The University of Stockholm the Institution of Psychology2004."},{"key":"e_1_2_6_6_1","first-page":"2827","article-title":"\u00dcber rezidivierende Nabelkoliken bei alteren Kindern","volume":"60","author":"Moro E","year":"1913","journal-title":"M\u00fcnch Medizin Wochen"},{"key":"e_1_2_6_7_1","volume-title":"The Child with Abdominal Pains","author":"Apley J","year":"1975"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1960.tb07739.x"},{"key":"e_1_2_6_9_1","unstructured":"Alfv\u00e9nG.Recurrent abdominal pain of non\u2010organic origin in childhood. Clinical muscular epidemiological endocrinological and aetiological aspects. Thesis Karolinska Institute Stockholm.1993."},{"issue":"2","key":"e_1_2_6_10_1","article-title":"Childhood functional gastrointestinal disorder","volume":"45","author":"Rasquin\u2010Weber A","year":"1999","journal-title":"Gut"},{"key":"e_1_2_6_11_1","first-page":"181","article-title":"Functional disorders: children and adolescents","volume":"15","author":"Hyams JA","year":"2016","journal-title":"Gastroenterology"},{"issue":"89","key":"e_1_2_6_12_1","article-title":"Paediatric functional abdominal pain disorders","volume":"6","author":"Thapar N","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05331.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14884"},{"key":"e_1_2_6_16_1","first-page":"625","article-title":"Intercostal neuralgia as a cause of abdominal pain and tenderness","volume":"42","author":"Carnett JB","year":"1926","journal-title":"Surg Gynecol Obst"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2414-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000685"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-015-0064-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004805"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00585.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(97)90047-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1057"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02491.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12728.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12706.x"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T08:33:48Z","timestamp":1705998828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/apa.16946"],"URL":"https:\/\/doi.org\/10.1111\/apa.16946","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,18]]},"assertion":[{"value":"2023-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}