{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:58:26Z","timestamp":1782529106860,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if trial\u2010related blood sampling increases the risk of later red blood cell (RBC) transfusion in very preterm infants, we compared the volume of clinical\u2010 and trial\u2010related blood samples, in a specific trial and correlated to subsequent RBC transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For 193 very preterm infants, participating in the FortiColos trial (NCT03537365), trial\u2010related blood volume drawn was in accordance with ethical considerations established by the European Commission. Medical records were reviewed to assess the number and accumulated volume (mL\/kg) of blood samples (both clinical\u2010 and trial\u2010related). Data were compared with the need of RBC transfusions during the first 28\u2009days of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean (SD) gestational age and birth weight was 28\u2009\u00b1\u20091\u2009weeks and 1168\u2009\u00b1\u2009301\u2009g. In total, 11% of total blood volume was drawn for sampling (8.1\u2009\u00b1\u20095.1\u2009mL\/kg) and trial\u2010related sampling accounted for 1.6\u2009\u00b1\u20090.6\u2009mL\/kg. Trial\u2010related blood sampling had no impact on RBC transfusion (<jats:italic>p<\/jats:italic>\u2009=\u20090.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical blood sampling in very preterm infants is associated with blood loss and subsequent need for RBC transfusions. In a specific trial requiring blood samples, we found no additional burden of trial\u2010related blood sampling. The study suggests that trial\u2010related sampling is safe if European criteria are followed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16948","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T09:29:01Z","timestamp":1691746141000},"page":"2486-2492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trial\u2010related blood sampling and red blood cell transfusions in preterm infants"],"prefix":"10.1111","volume":"112","author":[{"given":"Anna Elisabet","family":"Lewis","sequence":"first","affiliation":[{"name":"Comparative Pediatrics and Nutrition University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Neonatology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-298X","authenticated-orcid":false,"given":"Susanne S.","family":"Kappel","sequence":"additional","affiliation":[{"name":"Comparative Pediatrics and Nutrition University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samya","family":"Hussain","sequence":"additional","affiliation":[{"name":"Comparative Pediatrics and Nutrition University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per T.","family":"Sangild","sequence":"additional","affiliation":[{"name":"Comparative Pediatrics and Nutrition University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital  Odense 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