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This study aims at reviewing conservative management modalities and compare outcomes and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was performed according to PRISMA guidelines of all English publications in MEDLINE and EMBASE databases. Search words were exomphalos OR omphalocoele AND conservative OR non\u2010operative AND management. Studies were scrutinised for patient demographics, co\u2010morbidities, mode of treatment, time to full feeds, time to full epithelialisation, length of stay, complications and mortality. Studies not specifically describing mode of management and\/or describing primary or staged surgical repairs were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial search resulted in 1243 studies. Forty\u2010two studies were deemed suitable offering 822 patients for analysis after excluding duplicates and non\u2010eligible studies. Management methods varied including painting with Alcohol, Mercurochrome, silver products, Povidone Iodine, honey and other materials. Mortality was mostly due to associated anomalies. There was mixed reporting of alcohol, silver, Povidone Iodine and mercury toxicity as well as infection during the course of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report has recognised the variations in topical substances employed for conservative management with no clear consensus. Reports on safety of different methods remain unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16961","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:28:30Z","timestamp":1694064510000},"page":"2293-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Choice of topical substances in the conservative management of Exomphalos \u2013 A systematic review"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-8746","authenticated-orcid":false,"given":"Ayman","family":"Goneidy","sequence":"first","affiliation":[{"name":"Chelsea Children's Hospital, Chelsea and Westminster Hospital NHS Foundation Trust Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amulya K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Chelsea Children's Hospital, Chelsea and Westminster Hospital NHS 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