{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:11Z","timestamp":1792124891477,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and harms of a short (7\u201310\u2009days) compared with a standard (10\u201314\u2009days) duration of antibiotics in culture\u2010proven neonatal sepsis for reducing all\u2010cause mortality, treatment failure and duration of hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline, EMBASE and Cochrane CENTRAL were searched for randomised trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included five studies, all conducted in India (447 infants with a gestational age greater than 32\u2009weeks). Except for one study, all studies were at high risk of bias. All\u2010cause mortality was reported in three studies with only one death reported in the standard duration regimen arm (243 patients, very low certainty). A meta\u2010analysis showed no evidence of the effect on treatment failure (RR of 1.47 [95% CI 0.48\u20134.50], 440 patients, five studies, very low certainty) of short\u2010term antibiotics. Short\u2010term antibiotic regimen shortened the duration of hospitalisation by 4\u2009days (mean difference of \u22124.04\u2009days [95% CI \u22125.47 to \u22122.61]; 4 studies; 371 patients; very low certainty).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among studies focused on infants born with a gestational age greater than 32\u2009weeks, short\u2010term administration of antibiotics may shorten the duration of hospitalisation, but the evidence is very uncertain. The evidence on other predefined outcomes is very uncertain to draw definite conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16972","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:14:26Z","timestamp":1694600066000},"page":"56-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short course of intravenous antibiotics in the treatment of uncomplicated proven neonatal bacterial sepsis: A systematic review"],"prefix":"10.1111","volume":"113","author":[{"given":"Alanoud","family":"Aljarbou","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"},{"name":"Department of Pediatrics, College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cuello","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"},{"name":"Michael G. DeGroote Cochrane Canada &amp; MacGRADE Centres  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-0511","authenticated-orcid":false,"given":"Ana Teresa Figueiredo Stochero","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu079"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003314"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181958769"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60496-7"},{"issue":"5","key":"e_1_2_12_7_1","first-page":"1","article-title":"Antibiotic regimens for early\u2010onset neonatal sepsis","volume":"5","author":"Korang SK","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1707"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05785-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13518"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.5.394"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/665010"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml054"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq012"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-03794-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_17_1","article-title":"Cochrane handbook for systematic reviews of interventions version 5.1. 0 (updated march 2011)","volume":"2","author":"Deeks JJ","year":"2011","journal-title":"Cochrane Collaboration"},{"key":"e_1_2_12_18_1","unstructured":"Sch\u00fcnemannH Bro\u017cekJ GuyattG OxmanAe Group GW. 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McMaster University 2015 (developed by Evidence Prime Inc.).2021."}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.16972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T06:42:39Z","timestamp":1712299359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.16972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/apa.16972"],"URL":"https:\/\/doi.org\/10.1111\/apa.16972","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}