{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:34Z","timestamp":1787013874500,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To document the prevalence, severity, hospital outcome and factors associated with acute kidney injury (AKI) in hospitalised children with sickle cell anaemia (SCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study involving children aged 0.5\u201317\u2009years with SCA requiring hospitalisation, we used serum creatinine level at 0 and 48\u2009h of hospitalisation to determine the presence of AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study involved 155 children with SCA aged 0.5\u201317\u2009years with a median (interquartile range) age of 7.8 (4.3\u201311.0) years. Acute kidney injury occurred in 27 (17.4%) children with 33.3% reaching stage 3. Hepatomegaly (81.5% vs. 55.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), splenomegaly (33.3% vs. 10.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), dipstick proteinuria (22.2% vs. 5.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and hematuria (29.6% vs. 3.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;0.001) were more common in those with AKI. In contrast, children with AKI had lower haematocrit (16.9% vs. 22.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;0.001) and serum bicarbonate (16.7 vs. 19.1\u2009mmoL\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) compared with those without AKI. Those with AKI had longer hospital stay (median [interquartile range]: 7 [4\u201312] days vs. 4 [3\u20136] days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AKI is common among hospitalised children with AKI and is associated with longer hospital stay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17025","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T03:29:23Z","timestamp":1698982163000},"page":"557-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute kidney injury is more common in hospitalised children with sickle cell anaemia in Africa"],"prefix":"10.1111","volume":"113","author":[{"given":"Adetokunbo Olayinka","family":"Joacquim","sequence":"first","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeseye Micheal","family":"Akinsete","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Lagos Nigeria"},{"name":"Department of Paediatrics, Faculty of Clinical Sciences, College of Medicine University of Lagos\/Lagos University Teaching Hospital  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-4794","authenticated-orcid":false,"given":"Christopher Imokhuede","family":"Esezobor","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Lagos Nigeria"},{"name":"Department of Paediatrics, Faculty of Clinical Sciences, College of Medicine University of Lagos\/Lagos University Teaching Hospital  Lagos 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