{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:22:35Z","timestamp":1784949755440,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare Presepsin (presepsin) levels in plasma and urine of uninfected newborn infants with perinatal asphyxia with those of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, we enrolled 25 uninfected full\u2010term infants with perinatal asphyxia and 19 controls. We measured presepsin levels in whole blood or urine. In neonates with perinatal asphyxia, we compared presepsin levels in blood and urine at four time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In neonates with perinatal asphyxia, blood and urinary presepsin levels matched each other at any time point. At admission, the median presepsin value in blood was similar in both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.74), while urinary levels were higher in hypoxic neonates (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). Perinatal asphyxia seemed to increase serum CRP and procalcitonin levels beyond normal cut\u2010off but not those of presepsin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In uninfected neonates with perinatal asphyxia, median blood and urinary presepsin levels matched each other at any point in the first 72\u2009h of life and seemed to be slightly affected by the transient renal impairment associated with perinatal hypoxia in the first 12\u2009h of life. Perinatal asphyxia did not influence presepsin levels within the first 72\u2009h of life, while those of CRP and procalcitonin increased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17031","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T09:22:19Z","timestamp":1699608139000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perinatal asphyxia does not influence presepsin levels in neonates: A prospective study"],"prefix":"10.1111","volume":"113","author":[{"given":"Chiara","family":"Maddaloni","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-9838","authenticated-orcid":false,"given":"Domenico Umberto","family":"De\u00a0Rose","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"},{"name":"PhD Course in Microbiology, Immunology, Infectious Diseases and Transplants (MIMIT), Faculty of Medicine and Surgery \u201cTor Vergata\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Perulli","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Fondazione Policlinico Universitario A. 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