{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:43:11Z","timestamp":1790314991657,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["135222"],"award-info":[{"award-number":["135222"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Predicting neurodevelopmental outcomes in hypoxic\u2010ischaemic encephalopathy (HIE) remains imprecise, despite advanced imaging and neurophysiological tests. We explored the predictive value of socio\u2010economic status (SES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort comprised 93 infants (59% male) with HIE, who had received therapeutic hypothermia. Patients underwent magnetic resonance imaging, and brain injuries were quantified using the Barkovich scoring system. Family SES was self\u2010reported using a questionnaire. Adverse outcomes were defined as mild to severely delayed development with a score of \u226485 in any domain at 2\u2009years of age, based on the Bayley Scales of Infant Development, Second Edition. Data are presented as odds ratios (OR) with 95% confidence intervals (95% CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple regression modelling revealed that higher parental education was strongly associated with good cognitive development, when adjusted for gestational age, serum lactate and brain injuries (OR 2.20, 95% CI 1.16\u20134.36). The effect size of parental education (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.786) was higher than one score for any brain injury using the Barkovich scoring system (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.356). The literacy environment had a significant effect on cognitive development in the 21 infants who had brain injuries (OR 40, 95% CI 3.70\u20131352).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parental education and the literacy environment influenced cognitive outcomes in patients with HIE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17058","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T15:22:44Z","timestamp":1702912964000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Higher parental education was associated with good cognitive outcomes in infants with hypoxic\u2010ischaemic encephalopathy"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6355-9915","authenticated-orcid":false,"given":"Zsuzsanna","family":"Varga","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MTA Center of Excellence Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-1111","authenticated-orcid":false,"given":"Csilla","family":"Andorka","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MTA Center of Excellence Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Pataki","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MTA Center of Excellence Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-3156","authenticated-orcid":false,"given":"Unoke","family":"Meder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, MTA Center of Excellence Semmelweis University  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