{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:27:02Z","timestamp":1792596422419,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Clusters of group B <jats:italic>Streptococcus<\/jats:italic> (GBS) infections in neonatal intensive care units (NICU) are poorly documented. We aimed to assess GBS cross\u2010transmission during an outbreak of GBS sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out between October and November 2021 in a French University Hospital. Neonatal intensive care unit (NICU) patients with GBS sepsis were included. Clinical data were retrieved from electronic patient records. Group B <jats:italic>Streptococcus<\/jats:italic> isolates were characterized at the molecular level using capsular genotyping and whole\u2010genome sequencing (WGS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The outbreak of GBS sepsis affected three very preterm neonates with a gestational age of less than 26\u2009weeks, including one recurrent male index case aged 26\u2009days, and two female secondary cases aged 5 and 17\u2009days. The microbiological investigation identified a GBS isolate of capsular type III and Sequence Type 17 as responsible for the four infectious episodes. Whole\u2010genome sequencing confirmed the identity between the isolates. The outbreak and the results of the microbiological investigations led to an immediate reinforcement of hygiene measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clustered cases of GBS infections in NICU and horizontal transmission of the hypervirulent GBS Sequence Type 17 are likely underestimated. Prospective investigation of all nosocomial cases using WGS should contribute to improving vigilance regarding GBS cross\u2010transmission and infection prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17095","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T14:13:15Z","timestamp":1704550395000},"page":"947-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outbreak of group B <i>Streptococcus<\/i> in a neonatal care unit confirmed by whole\u2010genome sequencing"],"prefix":"10.1111","volume":"113","author":[{"given":"Nicolas","family":"Delettre","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 CNRS, INSERM, Institut Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Billion","sequence":"additional","affiliation":[{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris Centre Universit\u00e9 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