{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:33:44Z","timestamp":1750941224950,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The pneumococcal conjugate vaccine, which covered seven serotypes of <jats:italic>Streptococcus pneumoniae<\/jats:italic> (PCV7), was introduced in Stockholm, Sweden, in 2007. It was replaced by a 13\u2010valent vaccine (PCV13) in 2011. We previously reported a decreased incidence of pneumonia and sinusitis among young children 4\u2009years after the introduction of the PCV7. This study followed the incidence of pneumonia, sinusitis, mastoiditis and meningitis for four more years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied validated hospital registry data covering children up to 17\u2009years of age, who were hospitalised in the Stockholm region from 2003 to 2016, when the child population peaked at 485\u2009687. All 11\u2009115 cases diagnosed with pneumonia, coded as bacterial pneumonia, sinusitis, mastoiditis, bacterial meningitis or empyema, were identified. The controls had viral pneumonia or pyelonephritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rates for children under 2\u2009years of age hospitalised for sinusitis, mastoiditis and meningitis decreased significantly by 61%\u201379% during the eight\u2010year post\u2010vaccination period. Hospitalisations for bacterial pneumonia decreased by 19%\u201325% in the same age group. These changes were probably due to both the vaccines and changes in diagnosis routines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effect of vaccination on children under 2\u2009years of age was sustained 8\u2009years after the introduction of the pneumococcal conjugate vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17108","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T05:55:08Z","timestamp":1705125308000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The pneumococcal conjugate vaccine had a sustained effect on Swedish children 8\u2009years after its introduction"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-3512","authenticated-orcid":false,"given":"Tobias","family":"Alfv\u00e9n","sequence":"first","affiliation":[{"name":"Department of Global Public Health Karolinska Institutet  Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital, South General Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0105-1865","authenticated-orcid":false,"given":"Rutger","family":"Bennet","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Granath","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Intervention and Technology, Division of ENT Diseases Karolinska Institutet  Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Hultman","family":"Dennison","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Intervention and Technology, Division of ENT Diseases Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30247-X"},{"key":"e_1_2_12_3_1","article-title":"Pneumococcal conjugate vaccines for preventing vaccine\u2010type invasive pneumococcal disease and X\u2010ray defined pneumonia in children less than two years of age","volume":"2009","author":"Lucero MG","year":"2009","journal-title":"Cochrane Database Syst 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