{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:03:42Z","timestamp":1792224222406,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["733001"],"award-info":[{"award-number":["733001"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim is to examine the risk of cerebral palsy, seizures\/epilepsy, visual\u2010 and hearing impairments, cancer, injury\/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a population\u2010based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91\u2009504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1\u2009960\u2009727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co\u2010morbidities using Kaplan\u2013Meier survival estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Children with congenital anomalies had higher risks of the co\u2010morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5\u201315.1) for cerebral palsy, 2.5 (95% CI 2.4\u20132.6) for seizures\/epilepsy, 40.8 (95% CI 33.2\u201350.2) for visual impairments, 10.0 (95% CI 9.2\u201310.9) for hearing loss, 3.6 (95% CI 3.2\u20134.2) for cancer, 1.5 (95% CI 1.4\u20131.5) for injuries\/poisoning and 2.4 (95% CI 1.7\u20133.4) for child abuse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with congenital anomalies were more likely to be diagnosed with the specified co\u2010morbidities compared to reference children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17136","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T12:19:48Z","timestamp":1707308388000},"page":"1024-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Higher risk of cerebral palsy, seizures\/epilepsy, visual\u2010 and hearing impairments, cancer, injury and child abuse in children with congenital anomalies: Data from the EUROlinkCAT study"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-9723","authenticated-orcid":false,"given":"Stine Kjaer","family":"Urhoj","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital University Hospital of Southern Denmark  Kolding Denmark"},{"name":"Section of Epidemiology, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Morris","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Loane","sequence":"additional","affiliation":[{"name":"Institute of Nursing and Health Research Ulster University  Londonderry Northern Ireland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ballardini","sequence":"additional","affiliation":[{"name":"IMER Registry, Centre for Clinical and Epidemiological Research University of Ferrara and Azienda Ospedaliero Universitario di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Barrachina\u2010Bonet","sequence":"additional","affiliation":[{"name":"Rare Disease Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Cavero\u2010Carbonell","sequence":"additional","affiliation":[{"name":"Rare Disease Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Coi","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology National Research Council  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Department of Knowledge Brokers THL Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Region Stockholm Academic Primary Health Care Centre  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Given","sequence":"additional","affiliation":[{"name":"Institute of Nursing and Health Research Ulster University  Londonderry Northern Ireland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Heino","sequence":"additional","affiliation":[{"name":"Department of Knowledge Brokers THL Finnish Institute for Health and Welfare  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Neville","sequence":"additional","affiliation":[{"name":"IMER Registry, Centre for Clinical and Epidemiological Research University of Ferrara and Azienda Ospedaliero Universitario di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Santoro","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology National Research Council  Pisa 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University Hospital of Southern Denmark  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-8573","authenticated-orcid":false,"given":"Mads","family":"Damkjaer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital University Hospital of Southern Denmark  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"WHO.Birth Defects. 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