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Eleven patients (44%) had received allogeneic stem cell transplantation and two patients autologous stem cell transplantation. Sixteen patients (64%) had been treated with radiotherapy, either total\u2010body (<jats:italic>n<\/jats:italic>\u2009=\u200911) or local (<jats:italic>n<\/jats:italic>\u2009=\u20095). The main indication for bisphosphonates was osteoporosis with vertebral compression fractures in 13\/25, osteonecrosis in 6\/25 and hypercalcaemia in 2\/25. The bisphosphonate treatment was started on average 13 (range 0\u201376) months after the diagnosis of the bone complication. Bisphosphonate treatment lasted between weeks (hypercalcaemia) to 5\u2009years (severe osteoporosis). Mild, non\u2010symptomatic hypophosphatemia (<jats:italic>n<\/jats:italic>\u2009=\u20098), hypocalcaemia (<jats:italic>n<\/jats:italic>\u2009=\u20096) and moderate, transient pain (<jats:italic>n<\/jats:italic>\u2009=\u20096) were the most common adverse effects. No severe side effects were observed even when bisphosphonates were administered concomitantly with chemotherapy. Bone mineral density significantly improved with the bisphosphonate treatment (mean lumbar spine <jats:italic>Z<\/jats:italic>\u2010score \u22121.17 vs. \u22120.07, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bisphosphonate treatment was well tolerated in this paediatric patient cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17143","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T12:58:02Z","timestamp":1707397082000},"page":"1446-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bisphosphonate treatment for skeletal complications in paediatric cancer\u2014Experience from a single tertiary centre"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-9291","authenticated-orcid":false,"given":"Pauliina","family":"Utriainen","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital and Pediatric Research Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Research Program Unit for Clinical and Molecular Metabolism, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalmari E. E.","family":"Stenberg","sequence":"additional","affiliation":[{"name":"Research Program Unit for Clinical and Molecular Metabolism, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim K.","family":"Vettenranta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital and Pediatric Research Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi M.","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital and Pediatric Research Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Research Program Unit for Clinical and Molecular Metabolism, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70548-5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494809"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3217"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.18.3262"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27300"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2539"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3447"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26624"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24563"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001793"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090407"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1499"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05082-8"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.02.001"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1950928"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16589"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.125583"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29183"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281033"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:54:17Z","timestamp":1715230457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,8]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/apa.17143"],"URL":"https:\/\/doi.org\/10.1111\/apa.17143","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,8]]},"assertion":[{"value":"2023-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}