{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:23Z","timestamp":1747183283623,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G041716N"],"award-info":[{"award-number":["G041716N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate changes over time in cause of death and making end\u2010of\u2010life decisions in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A follow\u2010back survey was conducted of all preterm infants who died between September 2016 and December 2017 in Flanders and Brussels, Belgium. Cause of death was obtained from the death certificate and information on end\u2010of\u2010life decisions (ELDs) through an anonymous questionnaire of the certifying physician. Results were compared with a previous study performed between August 1999 and July 2000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the cohort 1999\u20132000 and 2016\u20132017, respectively, 150 and 135 deaths were included. A significantly higher proportion of infants born before 26\u2009weeks of gestation was found in the 2016\u20132017 cohort (53% vs. 24% in 1999\u20132000, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Extreme immaturity (&lt;26\u2009weeks) remained the most prevalent cause with a significant increase in the 2016\u20132017 cohort (48% vs. 28% in 1999\u20132000, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The overall prevalence of ELDs was similar across study periods (61%). Non\u2010treatment decisions remained the most common ELD (36% and 37%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants born at the limits of viability have become more prevalent among infant deaths, possibly due to a change in attitude towards periviable births. Neither the process of making ELDs nor the cause of death has changed over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17153","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T11:29:16Z","timestamp":1707737356000},"page":"1257-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cause of death and making end\u2010of\u2010life decisions in preterm infants has not changed over time: A mortality follow\u2010back survey"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6830-2546","authenticated-orcid":false,"given":"Linde","family":"Goossens","sequence":"first","affiliation":[{"name":"Department of Neonatal Intensive Care Ghent University Hospital  Gent 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