{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:23:54Z","timestamp":1792034634466,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010761","name":"Svenska F\u00f6reningen f\u00f6r Allergologi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016290","name":"Insamlingsstiftelsen Cancer- och Allergifonden","doi-asserted-by":"publisher","award":["10668"],"award-info":[{"award-number":["10668"]}],"id":[{"id":"10.13039\/100016290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016290","name":"Insamlingsstiftelsen Cancer- och Allergifonden","doi-asserted-by":"publisher","award":["10935"],"award-info":[{"award-number":["10935"]}],"id":[{"id":"10.13039\/100016290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study explored whether early\u2010life factors, such as rhinovirus\u2010induced wheeze and allergic sensitisation, were related to asthma at 11\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We focused on 107 children aged 6\u201348\u2009months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008\u20132012. They also attended follow\u2010up visits at 11\u2009years of age and were compared with 46 age\u2010matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 62.6% of the acute wheeze cases had asthma at 11\u2009years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02\u20135.6). Other increased risks were parental heredity for asthma and\/or allergies (adjusted OR 3.4, 95% CI 1.1\u20139.9) and allergic sensitisation at 2\u2009years of age (adjusted OR 3.0, 95% CI 1.02\u20138.7). The highest prevalence of asthma was when children had both rhinovirus\u2010induced wheeze at inclusion and allergic sensitisation at 7\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17158","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T10:38:17Z","timestamp":1708339097000},"page":"1376-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rhinovirus\u2010induced wheeze was associated with asthma development in predisposed children"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-5202","authenticated-orcid":false,"given":"Idun","family":"Holmdahl","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Astrid Lindgren's Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"L\u00fcning","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Astrid Lindgren's Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina W\u00e4rnberg","family":"Gerdin","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Astrid Lindgren's Children's 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