{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:47:54Z","timestamp":1750916874025,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["CDS\u2010RED\u201000019\u201016"],"award-info":[{"award-number":["CDS\u2010RED\u201000019\u201016"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405053\/2013\u20104"],"award-info":[{"award-number":["405053\/2013\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study reports the bilateral association of Peters' anomaly and congenital aniridia in monozygotic twins subsequently diagnosed with Wilms tumour (WAGR syndrome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two monozygotic female twins were referred at age 2\u2009months with bilateral corneal opacity. A diagnosis of Peters' anomaly associated to aniridia was made in both eyes of both twins. Physical examination and ultrasonography were carried out at 12\u2009months of age to explore the possibility of WAGR\u2010related anomalies, specifically Wilms tumour. DNA were isolated and subjected to whole exome sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peters' anomaly associated to aniridia in both eyes as well as bilateral Wilms tumour in both children were diagnosed. Exome analyses showed a large heterozygous deletion encompassing 6\u2009648\u2009473\u2009bp in chromosome 11p13, using Integrative Genomics Viewer and AnnotSV software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WAGR syndrome is a rare contiguous gene deletion syndrome with a greater risk of developing Wilms tumour associated with Peters' anomaly and congenital aniridia. However, co\u2010occurrence of both anomalies was rarely reported in twins, and never in both eyes of monozygotic twins. Here, we report the bilateral association of Peters' anomaly and congenital aniridia in monozygotic twins with WAGR syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17160","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T11:43:52Z","timestamp":1708083832000},"page":"1420-1425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral Peters' anomaly, aniridia and Wilms tumour (<scp>WAGR<\/scp> syndrome) in monozygotic twins"],"prefix":"10.1111","volume":"113","author":[{"given":"Sebasti\u00e3o","family":"Cronemberger","sequence":"first","affiliation":[{"name":"Hospital S\u00e3o Geraldo Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L. B.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Surgery Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Sim\u00f5es e","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovita Lane Soares Santos","family":"Zanini","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Imaging Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Higino Gon\u00e7alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Geraldo Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana 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