{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:11:20Z","timestamp":1791576680742,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014684","name":"Scottish Cot Death Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Preterm infants are at increased risk of Sudden Infant Death Syndrome (SIDS) and frequently experience short central apnoeas which can occur in isolation or a repetitive pattern (periodic breathing). We investigated the relationship between central apnoeas experienced before and over the 6\u2009months after hospital discharge and cerebral oxygenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm infants born between 28 and 32\u2009weeks gestational age (GA) were studied during supine daytime sleep at 32\u201336\u2009weeks post menstrual age (PMA) (<jats:italic>n<\/jats:italic>\u2009=\u200940), 36\u201340\u2009weeks PMA (<jats:italic>n<\/jats:italic>\u2009=\u200927), 3\u2010months corrected age (CA) (<jats:italic>n<\/jats:italic>\u2009=\u200920) and 6\u2010months CA (<jats:italic>n<\/jats:italic>\u2009=\u200926). Cerebral tissue oxygenation (TOI), peripheral oxygenation (SpO<jats:sub>2<\/jats:sub>) and heart rate were recorded continuously. The percentage total sleep time (%TST) spent having central apnoeas at each study and cerebral fractional oxygen extraction (SpO<jats:sub>2<\/jats:sub>\u2010TOI\/SpO<jats:sub>2<\/jats:sub>) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>%TST spent with central apnoeas decreased with increasing age in both active sleep (AS) and quiet sleep (QS). TOI tended to be lower and cerebral fractional oxygen extraction higher at 3\u2009months compared to the other studies and this reached statistical significance compared to 32\u201336\u2009weeks in QS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The nadir in cerebral tissue oxygenation at 3\u2009months of age coincides with the peak risk period for SIDS and this may contribute to increased risk in these infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17166","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T17:12:42Z","timestamp":1708449162000},"page":"1298-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preterm infants experience a nadir in cerebral oxygenation during sleep three months after hospital discharge"],"prefix":"10.1111","volume":"113","author":[{"given":"Alicia K.","family":"Yee","sequence":"first","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisha","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon S.","family":"Siriwardhana","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"},{"name":"Monash Newborn Monash Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary S. 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